Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9691403 | 0.92 | TP53 (0.40) | TP53SLC1A5POLBSMN1; SMN2GPBAR1 | |
| SCHEMBL9691648 | 0.91 | TP53 (0.41) | TP53SLC1A5POLBSMN1; SMN2RXRA | |
| SCHEMBL10814309 | 0.91 | TP53 (0.45) | TP53SLC1A5POLBSMN1; SMN2RXRA | |
| SCHEMBL10818189 | 0.90 | TP53 (0.41) | TP53SLC1A5POLBSMN1; SMN2GPBAR1 | |
| SCHEMBL10646454 | 0.88 | POLB (0.41) | TP53POLBSMN1; SMN2GPBAR1SIRT1 | |
| SCHEMBL9691359 | 0.86 | POLB (0.44) | TP53POLBSMN1; SMN2SIRT1KDM4E | |
| SCHEMBL10649425 | 0.86 | POLB (0.40) | TP53POLBSMN1; SMN2GPBAR1SIRT1 | |
| SCHEMBL10646808 | 0.85 | POLB (0.39) | TP53POLBSMN1; SMN2GPBAR1SIRT1 | |
| SCHEMBL9691625 | 0.84 | NR1I2 (0.42) | SLC1A5POLBSMN1; SMN2SIRT1KDM4E | |
| SCHEMBL9691661 | 0.84 | TP53 (0.43) | TP53SLC1A5POLBSMN1; SMN2RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0071819-B2 | DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION | BAYER AG (DE) | 1992-06-10 | — | — | EP | disclosed |