Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9691359 | 0.94 | POLB (0.44) | NR1I2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9691648 | 0.93 | TP53 (0.41) | NR1I2MAPTKDM4EGAAPOLB | |
| SCHEMBL9691692 | 0.92 | KMT2A (0.43) | HTR1ASLC6A2SLC6A4SLC6A3LMNA | |
| SCHEMBL10914095 | 0.91 | POLB (0.46) | NR1I2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9691796 | 0.91 | HTR6 (0.43) | NR1I2LMNAKDM4EL3MBTL1GAA | |
| SCHEMBL10647671 | 0.89 | NR1I2 (0.39) | NR1I2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9690850 | 0.88 | GAA (0.40) | NR1I2MAPTKDM4EGAAPOLB | |
| SCHEMBL9690807 | 0.88 | POLB (0.44) | NR1I2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10647063 | 0.87 | POLB (0.43) | NR1I2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9690877 | 0.87 | HTR6 (0.43) | NR1I2HTR1ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0071819-B2 | DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION | BAYER AG (DE) | 1992-06-10 | — | — | EP | disclosed |
| EP-0071819-B1 | DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION | BAYER AG (DE) | 1987-04-22 | — | — | EP | disclosed |