Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.36 |
| ▸ | USP2 | O75604 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11090300 | 0.85 | L3MBTL1 (0.39) | L3MBTL1ALDH1A1KMT2AMAPTCYP3A4 | |
| SCHEMBL11394005 | 0.84 | MAPT (0.43) | L3MBTL1ALDH1A1KMT2AMAPTMAPK1 | |
| SCHEMBL13536722 | 0.79 | CYP3A4 (0.40) | ALDH1A1KMT2AMAPTCYP3A4CYP2C19 | |
| SCHEMBL11082543 | 0.70 | MAPT (0.42) | L3MBTL1ALDH1A1KMT2AMAPTMAPK1 | |
| SCHEMBL2582180 | 0.69 | QDPR (0.44) | ALDH1A1KMT2AMAPTCYP3A4CYP2C19 | |
| SCHEMBL31078567 | 0.69 | L3MBTL1 (0.35) | L3MBTL1ALDH1A1KMT2AMAPTCYP3A4 | |
| SCHEMBL1016428 | 0.69 | PDK4 (0.47) | SMN1; SMN2USP2HPGD | |
| SCHEMBL2263812 | 0.69 | — | — | |
| SCHEMBL8663120 | 0.68 | F13A1 (0.35) | L3MBTL1ALDH1A1KMT2AMAPTCYP3A4 | |
| SCHEMBL3549997 | 0.68 | CYP2D6 (0.37) | L3MBTL1ALDH1A1KMT2AMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0168350-B1 | Certain ring-fused pyrazolo [3,4-d]-pyridin-3-one derivatives | CIBA-GEIGY AG (CH) | 1992-05-06 | — | — | EP | disclosed |
| US-4814450-A | CENTRAL NERVOUS SYSTEM DISORDERS | CIBA-GEIGY CORPORATION (US) | 1989-03-21 | — | — | US | disclosed |
| US-4740512-A | Treating anxiety with certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives | CIBA-GEIGY CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4647566-A | Certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives in treating anxiety | CIBA-GEIGY CORPORATION (US) | 1987-03-03 | — | — | US | disclosed |
| US-4602014-A | NERVOUS SYSTEM DISORDERS | CIBA-GEIGY CORPORATION (US) | 1986-07-22 | — | — | US | disclosed |
| EP-0168350-A2 | Certain ring-fused pyrazolo [3,4-d]-pyridin-3-one derivatives | CIBA-GEIGY AG (CH) | 1986-01-15 | — | — | EP | disclosed |