Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689513 | 0.95 | TP53 (0.40) | SMN1; SMN2TP53POLBKDM4EGAA | |
| SCHEMBL10914095 | 0.89 | POLB (0.46) | SMN1; SMN2TP53POLBKMT2AMEN1 | |
| SCHEMBL11303089 | 0.88 | ALDH1A1 (0.48) | SMN1; SMN2TP53POLBKMT2AMEN1 | |
| SCHEMBL9691359 | 0.86 | POLB (0.44) | SMN1; SMN2TP53POLBKMT2AMEN1 | |
| SCHEMBL10647063 | 0.85 | POLB (0.43) | SMN1; SMN2TP53POLBKMT2AMEN1 | |
| SCHEMBL9690807 | 0.84 | POLB (0.44) | SMN1; SMN2TP53POLBKMT2AMEN1 | |
| SCHEMBL10647317 | 0.84 | POLB (0.42) | SMN1; SMN2TP53POLBKMT2AMEN1 | |
| SCHEMBL11003624 | 0.83 | KDM4E (0.52) | TP53KDM4EGAANR1I2 | |
| SCHEMBL10647279 | 0.82 | NPC1 (0.43) | SMN1; SMN2POLBKMT2AMEN1KDM4E | |
| SCHEMBL10645304 | 0.82 | POLB (0.41) | SMN1; SMN2TP53POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0071819-B2 | DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION | BAYER AG (DE) | 1992-06-10 | — | — | EP | disclosed |