Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9691830 | 0.95 | SMN1; SMN2 (0.39) | TP53KDM4EGAASMN1; SMN2NR1I2 | |
| SCHEMBL11303089 | 0.87 | ALDH1A1 (0.48) | TP53KDM4EGAASMN1; SMN2NR1I2 | |
| SCHEMBL9691661 | 0.87 | TP53 (0.43) | TP53KDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL9691648 | 0.86 | TP53 (0.41) | TP53KDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL11004701 | 0.84 | KDM4E (0.50) | TP53KDM4EGAANR1I2ALDH1A1 | |
| SCHEMBL10914095 | 0.84 | POLB (0.46) | TP53KDM4EGAASMN1; SMN2NR1I2 | |
| SCHEMBL9690807 | 0.83 | POLB (0.44) | TP53KDM4EGAASMN1; SMN2NR1I2 | |
| SCHEMBL9691359 | 0.81 | POLB (0.44) | TP53KDM4EGAASMN1; SMN2NR1I2 | |
| SCHEMBL9691722 | 0.80 | KDM4E (0.43) | TP53KDM4EGAASMN1; SMN2NR1I2 | |
| SCHEMBL10647063 | 0.80 | POLB (0.43) | TP53KDM4EGAASMN1; SMN2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0071819-B2 | DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION | BAYER AG (DE) | 1992-06-10 | — | — | EP | disclosed |
| EP-0071819-B1 | DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION | BAYER AG (DE) | 1987-04-22 | — | — | EP | disclosed |