Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30954347 | 0.93 | CCKBR (0.60) | CCKBRMAPTSMN1; SMN2 | |
| SCHEMBL5698825 | 0.93 | CCKBR (0.60) | CCKBRMAPTSMN1; SMN2 | |
| SCHEMBL30044625 | 0.93 | CCKBR (0.60) | CCKBRMAPTSMN1; SMN2 | |
| SCHEMBL5672901 | 0.93 | CCKBR (0.60) | CCKBRMAPTSMN1; SMN2 | |
| SCHEMBL10736517 | 0.93 | CCKBR (0.60) | CCKBRMAPTSMN1; SMN2 | |
| SCHEMBL9690349 | 0.87 | CCKBR (0.52) | CCKBR | |
| SCHEMBL7445733 | 0.85 | GAA (0.52) | MAPT | |
| SCHEMBL8283797 | 0.83 | CCKBR (0.61) | CCKBRMAPTSMN1; SMN2 | |
| SCHEMBL7438830 | 0.82 | GAA (0.52) | MAPT | |
| SCHEMBL7342505 | 0.82 | ACE (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166354-B1 | BENZOFUSED LACTAM COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1992-08-05 | — | — | EP | disclosed |
| US-4873235-A | COUPLING KETO ESTER WITH LACTAM; ANGIOTENSIN CONVERTING ENZYME INHIBITORS | MERCK & CO., INC. (US) | 1989-10-10 | — | — | US | disclosed |
| US-4692522-A | Benzofused lactams useful as cholecystokinin antagonists | MERCK & CO., INC. (US) | 1987-09-08 | — | — | US | disclosed |
| US-4684645-A | GASTROINTESTINAL AND NERVOUS SYSTEM DISORDERS | MERCK & CO., INC. (US) | 1987-08-04 | — | — | US | disclosed |