Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 11/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | F12 | P00748 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363507 | 0.90 | MAPT (0.46) | PDE4D | |
| SCHEMBL7996902 | 0.83 | SMN1; SMN2 (0.41) | TMEM97SIGMAR1PTGDR2 | |
| SCHEMBL9693215 | 0.83 | LMNA (0.51) | — | |
| SCHEMBL10563519 | 0.81 | GRIN2B (0.48) | TMEM97SIGMAR1PTGDR2DHFR | |
| SCHEMBL9693096 | 0.78 | MAPT (0.46) | — | |
| SCHEMBL12702905 | 0.78 | KDM4E (0.42) | — | |
| SCHEMBL4399188 | 0.76 | TMEM97 (0.49) | TMEM97SIGMAR1DHFRADORA3PDE4D | |
| SCHEMBL9693922 | 0.76 | CHRM1 (0.41) | CHRM5 | |
| SCHEMBL21841717 | 0.75 | DHFR (0.58) | TMEM97SIGMAR1DHFRHTR1ACHRM5 | |
| SCHEMBL16210173 | 0.75 | TMEM97 (0.52) | TMEM97SIGMAR1PTGDR2DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0168350-B1 | Certain ring-fused pyrazolo [3,4-d]-pyridin-3-one derivatives | CIBA-GEIGY AG (CH) | 1992-05-06 | — | — | EP | disclosed |
| US-4814450-A | CENTRAL NERVOUS SYSTEM DISORDERS | CIBA-GEIGY CORPORATION (US) | 1989-03-21 | — | — | US | disclosed |
| US-4740512-A | Treating anxiety with certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives | CIBA-GEIGY CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4647566-A | Certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives in treating anxiety | CIBA-GEIGY CORPORATION (US) | 1987-03-03 | — | — | US | disclosed |
| US-4602014-A | NERVOUS SYSTEM DISORDERS | CIBA-GEIGY CORPORATION (US) | 1986-07-22 | — | — | US | disclosed |
| EP-0168350-A2 | Certain ring-fused pyrazolo [3,4-d]-pyridin-3-one derivatives | CIBA-GEIGY AG (CH) | 1986-01-15 | — | — | EP | disclosed |