Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 7/20 | 0.44 |
| ▸ | PDE6D | O43924 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9695626 | 0.84 | KCNH2 (0.61) | TP53NR4A2KCNH2PDE6D | |
| SCHEMBL9535735 | 0.78 | TP53 (0.51) | TP53POLBMAPTLMNANR4A2 | |
| Hydrochloric Acid SCHEMBL9537452 | 0.77 | TP53 (0.50) | TP53POLBMAPTLMNANR4A2 | |
| Hydrochloric Acid SCHEMBL9741375 | 0.76 | KCNH2 (0.70) | TP53POLBMAPTLMNANR4A2 | |
| Hydrochloric Acid SCHEMBL11271768 | 0.76 | KCNH2 (0.69) | TP53POLBMAPTLMNANR4A2 | |
| SCHEMBL7897746 | 0.75 | HTR3A (0.53) | TP53LMNANR4A2KCNH2PDE6D | |
| SCHEMBL9544483 | 0.72 | KCNH2 (0.61) | TP53NR4A2KCNH2PDE6D | |
| SCHEMBL9696761 | 0.71 | CYP2D6 (0.43) | TP53MAPTKCNH2 | |
| SCHEMBL17966778 | 0.71 | TP53 (0.54) | TP53POLBMAPTLMNATHRB | |
| SCHEMBL9258632 | 0.71 | HRH1 (0.56) | TP53KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992006086-A1 | NOVEL 4-PIPERIDINYLCARBONYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-04-16 | — | — | WO | disclosed |