Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 3/20 | 0.37 |
| ▸ | GABRD | O14764 | 3/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21751965 | 0.85 | NOTUM (0.54) | NOTUMKDM5AKDM5BKDM4EALDH1A1 | |
| SCHEMBL5842251 | 0.81 | NOTUM (0.45) | NOTUMPTPN1KDM5AKDM5BKDM4E | |
| SCHEMBL1155956 | 0.79 | ALDH1A1 (0.40) | KDM4EALDH1A1KMT2APPARAHTT | |
| SCHEMBL4527898 | 0.77 | KMT2A (0.49) | KDM4EALDH1A1KMT2ACA12CA9 | |
| SCHEMBL7260781 | 0.77 | PRKCI (0.34) | PTPN1PTPN11KDM4EALDH1A1HCAR2 | |
| SCHEMBL1126724 | 0.73 | NOTUM (0.47) | NOTUMALDH1A1KMT2AGABRA1GABRB2 | |
| Isobutyramide SCHEMBL28976391 | 0.73 | NOTUM (0.39) | NOTUMALDH1A1KMT2A | |
| SCHEMBL28270009 | 0.73 | EPHX2 (0.36) | PTPN1PTPN11ALDH1A1KMT2AHCAR2 | |
| SCHEMBL70047 | 0.71 | NOTUM (0.65) | NOTUMKDM4EALDH1A1KMT2ACA12 | |
| SCHEMBL5154187 | 0.71 | PTPN1 (0.46) | PTPN1PTPN11KDM5AKDM5BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7875745-B2 | {1-[(2S,3S)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-(3,5-dimethoxy-4- methylphenyl)-3-hydroxylpropyl]-1H-pyrrol-3-yl}acetic acid; for urinary system disease selected from the group of prostatic hypertrophy, neurogenic bladder dysfunction disease, dysuria, pollakiuria, night urination and urodynia | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-01-25 | — | — | US | disclosed |
| US-20070149595-A1 | Compounds having lysophosphatidic acid receptor antagonism and uses thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-06-28 | — | — | US | disclosed |
| EP-0231394-B1 | NOVEL POLYMERS OF3,4-SUBSTITUTED PYRROLE COMPOUND AND PROCESSFOR THEIR PREPARATION | NIPPON SODA CO., LTD. (JP) | 1991-03-13 | — | — | EP | disclosed |
| US-4816536-A | ELECTROCHROMISM ELEMENTS | NIPPON SODA CO., LTD. (JP) | 1989-03-28 | — | — | US | disclosed |
| EP-0231394-A1 | NOVEL POLYMERS OF3,4-SUBSTITUTED PYRROLE COMPOUND AND PROCESSFOR THEIR PREPARATION | NIPPON SODA CO., LTD. (JP) | 1987-08-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149595-A1 | Compounds having lysophosphatidic acid receptor antagonism and uses thereof | LPAR2, LPAR1, LPAR5 | NOTUM 3884/4885PTPN1 930/4885PTPN11 1215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.