Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9697582 | 0.99 | TSHR (0.46) | TSHRSMN1; SMN2USP2NOD2NOD1 | |
| SCHEMBL3360368 | 0.94 | TSHR (0.48) | TSHRSMN1; SMN2USP2NOD2NOD1 | |
| Hydrochloric Acid SCHEMBL9697076 | 0.93 | TSHR (0.47) | TSHRSMN1; SMN2USP2NOD2NOD1 | |
| SCHEMBL9753017 | 0.92 | TSHR (0.45) | TSHRSMN1; SMN2USP2NOD2NOD1 | |
| Hydrochloric Acid SCHEMBL9753453 | 0.85 | TSHR (0.46) | TSHRSMN1; SMN2USP2NOD2NOD1 | |
| SCHEMBL9732994 | 0.83 | NPC1 (0.46) | TSHRSMN1; SMN2USP2MAPTLMNA | |
| SCHEMBL9697916 | 0.82 | NOD2 (0.42) | TSHRSMN1; SMN2NOD2NOD1MAPT | |
| SCHEMBL9733161 | 0.82 | USP2 (0.40) | TSHRSMN1; SMN2USP2KDM1ACYP1A2 | |
| Hydrochloric Acid SCHEMBL9733674 | 0.82 | NPC1 (0.46) | TSHRSMN1; SMN2USP2MAPTLMNA | |
| SCHEMBL9695933 | 0.82 | TSHR (0.48) | TSHRSMN1; SMN2USP2NOD2NOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149700-A | Antiarrhythmic agent | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-22 | — | — | US | claimed |
| US-5149700-A | Antiarrhythmic agent | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-22 | — | — | US | disclosed |
| WO-1991018904-A1 | SUBSTITUTED ARYLSULFONAMIDES AND BENZAMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-12-12 | — | — | WO | disclosed |