Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 3/20 | 0.58 |
| ▸ | NOS2 | P35228 | 2/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3756442 | 0.92 | NCF1 (0.56) | NCF1NOS2NOS1PTK2CYP1A2 | |
| SCHEMBL5911169 | 0.81 | NCF1 (0.63) | NCF1NOS2PTK2CYP1A2HIF1A | |
| SCHEMBL6602159 | 0.79 | NCF1 (0.61) | NCF1NOS2PTK2CYP1A2HIF1A | |
| SCHEMBL5943623 | 0.77 | NCF1 (0.58) | NCF1NOS2NOS1PTK2CYP1A2 | |
| Iodide SCHEMBL28842235 | 0.75 | NCF1 (0.56) | NCF1NOS2PTK2CYP1A2HIF1A | |
| SCHEMBL31650826 | 0.74 | NCF1 (1.00) | NCF1NOS2PTK2CYP1A2HIF1A | |
| SCHEMBL12383278 | 0.74 | NCF1 (0.76) | NCF1NOS2PTK2CYP1A2HIF1A | |
| SCHEMBL4263734 | 0.74 | NCF1 (1.00) | NCF1NOS2PTK2CYP1A2HIF1A | |
| SCHEMBL29946313 | 0.74 | NCF1 (1.00) | NCF1NOS2PTK2CYP1A2HIF1A | |
| SCHEMBL726956 | 0.72 | CYP2C19 (0.51) | NOS2NOS1PTK2CYP1A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149700-A | Antiarrhythmic agent | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-22 | — | — | US | disclosed |
| WO-1991018904-A1 | SUBSTITUTED ARYLSULFONAMIDES AND BENZAMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-12-12 | — | — | WO | disclosed |