Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 16/20 | 0.73 |
| ▸ | TACR1 | P25103 | 2/20 | 0.73 |
| ▸ | TACR2 | P21452 | 1/20 | 0.73 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9544433 | 0.88 | HRH1 (0.58) | HRH1TACR1TACR2SSTR5KCNH2 | |
| SCHEMBL9264751 | 0.88 | HRH1 (0.72) | HRH1TACR1TACR2KCNH2CYP2D6 | |
| SCHEMBL9259670 | 0.87 | HRH1 (0.69) | HRH1TACR1TACR2SSTR5KCNH2 | |
| SCHEMBL9196229 | 0.85 | HRH1 (0.66) | HRH1TACR1TACR2SSTR5KCNH2 | |
| SCHEMBL9196398 | 0.85 | HRH1 (1.00) | HRH1TACR1TACR2SSTR5KCNH2 | |
| SCHEMBL9259609 | 0.84 | HRH1 (0.67) | HRH1TACR1TACR2KCNH2CYP2D6 | |
| SCHEMBL9258364 | 0.83 | HRH1 (0.71) | HRH1TACR1TACR2 | |
| SCHEMBL7474308 | 0.83 | HRH1 (0.62) | HRH1TACR1TACR2KCNH2NR4A2 | |
| SCHEMBL15568226 | 0.82 | HRH1 (0.63) | HRH1TACR1TACR2KCNH2 | |
| SCHEMBL9259200 | 0.82 | HRH1 (0.63) | HRH1TACR1TACR2KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992006086-A1 | NOVEL 4-PIPERIDINYLCARBONYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-04-16 | — | — | WO | disclosed |