Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 15/20 | 0.62 |
| ▸ | TACR1 | P25103 | 2/20 | 0.62 |
| ▸ | TACR2 | P21452 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.61 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.61 |
| ▸ | HTR3A | P46098 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7468353 | 0.94 | HRH1 (0.57) | HRH1TACR1TACR2KCNH2NR4A2 | |
| Hydrochloric Acid SCHEMBL7887857 | 0.90 | HTR3A (0.52) | HRH1TACR1TACR2KCNH2NR4A2 | |
| SCHEMBL9264751 | 0.86 | HRH1 (0.72) | HRH1TACR1TACR2KCNH2CHRM1 | |
| SCHEMBL9196229 | 0.85 | HRH1 (0.66) | HRH1TACR1TACR2KCNH2CHRM1 | |
| SCHEMBL9259609 | 0.84 | HRH1 (0.67) | HRH1TACR1TACR2KCNH2CHRM1 | |
| SCHEMBL15569315 | 0.84 | HRH1 (0.62) | HRH1TACR1TACR2CYP2D6TP53 | |
| SCHEMBL9259670 | 0.83 | HRH1 (0.69) | HRH1TACR1TACR2KCNH2CYP2D6 | |
| SCHEMBL9697152 | 0.83 | HRH1 (0.73) | HRH1TACR1TACR2KCNH2NR4A2 | |
| SCHEMBL15568226 | 0.83 | HRH1 (0.63) | HRH1TACR1TACR2KCNH2 | |
| SCHEMBL9259200 | 0.83 | HRH1 (0.63) | HRH1TACR1TACR2KCNH2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4908372-A | Antihistaminic piperidinyl benzimidazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-13 | — | — | US | claimed |
| WO-2014027053-A1 | BENZIMIDAZOLES FOR THE TREATMENT OF CANCER | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-02-20 | — | — | WO | disclosed |
| EP-0882038-B1 | SUBSTITUTED N-METHYL-N-(4-(PIPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | AVENTIS PHARMA INC (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6329392-B1 | ANTIALLERGENS | AVENTIS PHARMACEUTICALS, INC. | 2001-12-11 | — | — | US | disclosed |
| US-6297259-B1 | HISTAMINE RECEPTOR ANTAGONISTS AND TACHYKININ RECEPTOR ANTAGONISTS. | AVENTIS PHARMACEUTICALS INC. | 2001-10-02 | — | — | US | disclosed |
| US-5998439-A | RESPIRATORY SYSTEM DISORDERS | Hoescht Marion Roussel, Inc. (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0777666-B1 | SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | MERRELL PHARMA INC (US) | 1999-03-03 | — | — | EP | disclosed |
| EP-0882038-A1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(PIPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997030990-A1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(PIPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1997-08-28 | — | — | WO | disclosed |
| EP-0777666-A1 | NOVEL SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | MERRELL PHARMACEUTICALS INC. (US) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996006094-A1 | NOVEL SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | MERRELL PHARMACEUTICALS INC. (US) | 1996-02-29 | — | — | WO | disclosed |
| EP-0363963-B1 | Piperidinyl benzimidazoles as antihistamines | MERRELL DOW PHARMA (US) | 1995-04-26 | — | — | EP | disclosed |
| US-5380731-A | Antiallergic compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0561973-A1 | ANTIALLERGIC COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-09-29 | — | — | EP | disclosed |
| US-5182399-A | Process for preparing piperidinyl benzimidazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-01-26 | — | — | US | disclosed |
| WO-1992010491-A1 | ANTIALLERGIC COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-06-25 | — | — | WO | disclosed |
| EP-0363963-A1 | Piperidinyl benzimidazoles as antihistamines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-04-18 | — | — | EP | disclosed |
| US-4908372-A | Antihistaminic piperidinyl benzimidazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-13 | — | — | US | disclosed |