Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.58 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.58 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.57 |
| ▸ | HRH1 | P35367 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531944 | 0.96 | HRH3 (0.61) | CHRNB2CHRNB4CHRNA3CHRNA4HRH3 | |
| Oxalic Acid SCHEMBL9528802 | 0.93 | KDM4E (0.54) | CHRNB2CHRNB4CHRNA3CHRNA4HRH3 | |
| Oxalic Acid SCHEMBL9528171 | 0.91 | HRH3 (0.60) | CHRNB2CHRNB4CHRNA3CHRNA4HRH3 | |
| Oxalic Acid SCHEMBL9528825 | 0.88 | KDM4E (0.53) | CHRNB2CHRNB4CHRNA3CHRNA4HRH3 | |
| Oxalic Acid SCHEMBL9531846 | 0.88 | HRH3 (0.64) | CHRNB2CHRNB4CHRNA3CHRNA4HRH3 | |
| Oxalic Acid SCHEMBL9529862 | 0.87 | HRH3 (0.53) | CHRNB2CHRNB4CHRNA3CHRNA4HRH3 | |
| Oxalic Acid SCHEMBL9527881 | 0.86 | ALDH1A1 (0.64) | CHRNB2CHRNB4CHRNA3CHRNA4KDM4E | |
| SCHEMBL9527959 | 0.86 | HRH3 (0.55) | CHRNB2CHRNB4CHRNA3CHRNA4HRH3 | |
| Oxalic Acid SCHEMBL9369576 | 0.85 | HRH3 (0.62) | HRH3KDM4E | |
| SCHEMBL9527422 | 0.85 | KDM4E (0.54) | CHRNB2CHRNB4CHRNA3CHRNA4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1062349-A | Be used as the croak pyridine class of the 3-replacement of medicine | SMITH KLINE FRENCH LAB (GB) | 1992-07-01 | — | — | CN | disclosed |
| WO-1992002501-A1 | 3-SUBSTITUTED PIPERIDINE DERIVATIVES | SMITHKLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-02-20 | — | — | WO | disclosed |