Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.53 |
| ▸ | HRH2 | P25021 | 4/20 | 0.53 |
| ▸ | HRH1 | P35367 | 4/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9528802 | 0.89 | KDM4E (0.54) | HRH3KDM4EALDH1A1LMNACHRNB2 | |
| Oxalic Acid SCHEMBL9531846 | 0.88 | HRH3 (0.64) | HRH3CHRNB2CHRNB4CHRNA3CHRNA4 | |
| Oxalic Acid SCHEMBL9528825 | 0.88 | KDM4E (0.53) | HRH3KDM4EALDH1A1LMNAMAOB | |
| Oxalic Acid SCHEMBL9697600 | 0.87 | CHRNB2 (0.58) | HRH3HRH1KDM4EALDH1A1LMNA | |
| Oxalic Acid SCHEMBL9373478 | 0.83 | HRH3 (0.59) | HRH3CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL9531944 | 0.82 | HRH3 (0.61) | HRH3HRH2HRH1CHRNB2CHRNB4 | |
| SCHEMBL9527998 | 0.82 | MEN1 (0.51) | HRH3ALDH1A1LMNAMAOBMAOA | |
| Oxalic Acid SCHEMBL9368390 | 0.81 | KMT2A (0.56) | HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL9527422 | 0.81 | KDM4E (0.54) | HRH3KDM4EALDH1A1LMNACHRNB2 | |
| SCHEMBL9528653 | 0.81 | HRH3 (0.53) | HRH3MAOBMAOAACHECHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0542844-A1 | 3-SUBSTITUTED PIPERIDINE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-05-26 | — | — | EP | disclosed |
| WO-1992002501-A1 | 3-SUBSTITUTED PIPERIDINE DERIVATIVES | SMITHKLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-02-20 | — | — | WO | disclosed |