Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | GPR6 | P46095 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9631274 | 0.94 | KCNH2 (0.42) | KCNH2HRH1SSTR5DRD4SIGMAR1 | |
| SCHEMBL9699544 | 0.85 | HRH1 (0.47) | KCNH2HRH1SSTR5DRD4GPR6 | |
| SCHEMBL10428946 | 0.85 | SSTR5 (0.57) | KCNH2HRH1SSTR5DRD4SIGMAR1 | |
| SCHEMBL9630331 | 0.83 | KCNH2 (0.54) | KCNH2HRH1SSTR5DRD4SIGMAR1 | |
| SCHEMBL9698779 | 0.83 | HRH1 (0.45) | KCNH2HRH1SSTR5DRD4GPR6 | |
| SCHEMBL9697289 | 0.82 | HRH1 (0.43) | KCNH2HRH1SSTR5DRD4GPR6 | |
| SCHEMBL9389243 | 0.82 | KCNH2 (0.39) | KCNH2SSTR5NR4A2 | |
| SCHEMBL9630368 | 0.82 | HRH1 (0.43) | KCNH2HRH1SSTR5DRD4SIGMAR1 | |
| Bromide SCHEMBL9698669 | 0.81 | KCNH2 (0.50) | KCNH2HRH1GPR6ENPP2NR4A2 | |
| SCHEMBL9537031 | 0.80 | SLC6A9 (0.42) | KCNH2HRH1SSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE33833-E | Intermediates for antihistamines, antiserotonine agents | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-02-25 | — | — | US | disclosed |
| US-4820822-A | ANTIHISTAMINE, ANTISEROTONINE AGENTS | JANSSEN PHARMACEUTICA (BE) | 1989-04-11 | — | — | US | disclosed |
| US-4760074-A | Novel-N-(bicyclic heterocyclyl)-4-piperidinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-07-26 | — | — | US | disclosed |
| EP-0099139-B1 | NOVEL N-(BICYCLIC HETEROCYCLYL)-4-PIPERIDINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-02-11 | — | — | EP | disclosed |
| US-4556660-A | ANTIALLERGENS | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-12-03 | — | — | US | disclosed |
| EP-0099139-A2 | Novel N-(bicyclic heterocyclyl)-4-piperidinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-01-25 | — | — | EP | disclosed |