Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | EED | O75530 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 3/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MLNR | O43193 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HLA-A | P04439 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9699544 | 0.94 | HRH1 (0.47) | HRH1EEDKCNH2SSTR5NR4A2 | |
| SCHEMBL9630130 | 0.89 | HRH1 (0.53) | HRH1EEDKCNH2SSTR5NR4A2 | |
| SCHEMBL9690941 | 0.88 | HRH1 (0.41) | HRH1EEDKCNH2SSTR5KAT2B | |
| SCHEMBL9630461 | 0.87 | HTR1A (0.40) | HRH1EEDKCNH2SSTR5NR4A2 | |
| SCHEMBL9631274 | 0.86 | KCNH2 (0.42) | HRH1EEDKCNH2SSTR5KAT2B | |
| SCHEMBL9629312 | 0.84 | SLC6A9 (0.47) | EEDKCNH2SSTR5ROCK2ROCK1 | |
| SCHEMBL8133192 | 0.84 | SSTR5 (0.39) | HRH1EEDKCNH2SSTR5NR4A2 | |
| SCHEMBL4987366 | 0.83 | HRH1 (0.58) | HRH1EEDKCNH2SSTR5NR4A2 | |
| Water SCHEMBL6662104 | 0.83 | KCNH2 (0.42) | HRH1EEDKCNH2SSTR5NR4A2 | |
| SCHEMBL9630210 | 0.83 | EED (0.39) | HRH1EEDKCNH2SSTR5NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151424-A | Antiallergens or antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| US-5071846-A | Anti-hystaminic [(bicyclic heterocyclyl) methyl and --hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-10 | — | — | US | disclosed |
| US-4988689-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-29 | — | — | US | disclosed |