Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.51 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.50 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9698507 | 1.00 | THRA (0.56) | THRATHRBNR5A1CYSLTR2CYSLTR1 | |
| SCHEMBL224388 | 1.00 | THRA (0.56) | THRATHRBNR5A1CYSLTR2CYSLTR1 | |
| SCHEMBL9149513 | 0.89 | ALDH1A1 (0.48) | THRATHRBCYSLTR2CYSLTR1LTA4H | |
| SCHEMBL9698493 | 0.88 | NR5A1 (0.51) | THRATHRBNR5A1CYSLTR2CYSLTR1 | |
| SCHEMBL12433812 | 0.84 | THRA (0.55) | THRATHRBLMNAHTTS1PR1 | |
| SCHEMBL7456145 | 0.83 | THRA (0.54) | THRATHRBESR1LMNAHTT | |
| SCHEMBL30611015 | 0.82 | ALDH1A1 (0.48) | THRATHRBALDH1A1GAANR1I2 | |
| SCHEMBL28516656 | 0.82 | ALDH1A1 (0.48) | THRATHRBALDH1A1GAANR1I2 | |
| SCHEMBL5083146 | 0.82 | ALDH1A1 (0.52) | THRATHRBESR1LTA4HALDH1A1 | |
| SCHEMBL13341488 | 0.81 | THRA (0.51) | THRATHRBNR5A1ESR1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5147864-A | Bronchodilator agent, antianaphylactic agent, antishock agent, cardiotonic agent and anticarcinogenic agent | AMERICAN CYANAMID COMPANY (US) | 1992-09-15 | — | — | US | disclosed |
| US-4983592-A | Bis-arylphosphate ester antagonists of platelet activating factor | AMERICAN CYANAMID CO. (US) | 1991-01-08 | — | — | US | disclosed |
| EP-0374513-A2 | Novel bis-arylphosphate ester antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1990-06-27 | — | — | EP | disclosed |