Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.35 |
| ▸ | APP | P05067 | 3/20 | 0.35 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | DBH | P09172 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL561713 | 0.80 | KDM4E (0.50) | KDM4ELMNAMMP1MMP3MMP7 | |
| E637 SCHEMBL14990891 | 0.78 | KDM4E (0.48) | KDM4ELMNAMMP1MMP3MMP7 | |
| SCHEMBL6998427 | 0.78 | KDM4E (0.52) | KDM4ELMNAMMP1MMP3MMP7 | |
| SCHEMBL31266634 | 0.78 | AKR1B1 (0.43) | KDM4ELMNACA2CAMK2AAKR1B1 | |
| E637 SCHEMBL41817 | 0.76 | KDM4E (0.55) | KDM4ELMNAMMP1MMP3MMP7 | |
| E637 SCHEMBL1870685 | 0.76 | KDM4E (0.55) | KDM4ELMNAMMP1MMP3MMP7 | |
| E637 SCHEMBL23309786 | 0.74 | KDM4E (0.53) | KDM4ELMNAMMP1MMP3MMP7 | |
| E637 SCHEMBL6657728 | 0.74 | KDM4E (0.53) | KDM4ELMNAMMP1MMP3MMP7 | |
| SCHEMBL9700110 | 0.74 | KDM4E (0.48) | KDM4ELMNAMMP1MMP3MMP7 | |
| E637 SCHEMBL8026696 | 0.74 | KDM4E (0.53) | KDM4ELMNAMMP1MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992012131-A1 | 3-HYDROXYPYRIDIN-4-ONE DERIVATIVES AS PHARMACEUTICAL COMPOSITIONS | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1992-07-23 | — | — | WO | disclosed |
| EP-0494754-A1 | 3-hydroxypyridin-4-one derivatives as pharmaceutical compositions | BRITISH TECHNOLOGY GROUP LTD (GB) | 1992-07-15 | — | — | EP | disclosed |