Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 6/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | DBH | P09172 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9700110 | 0.83 | KDM4E (0.48) | KDM4ELMNAAPPFTOTYR | |
| E637 SCHEMBL41817 | 0.81 | KDM4E (0.55) | KDM4ELMNAAPPFTOMMP1 | |
| E637 SCHEMBL1870685 | 0.81 | KDM4E (0.55) | KDM4ELMNAAPPFTOMMP1 | |
| SCHEMBL561713 | 0.81 | KDM4E (0.50) | KDM4ELMNAAPPFTOMMP1 | |
| E637 SCHEMBL8026696 | 0.79 | KDM4E (0.53) | KDM4ELMNAAPPFTOMMP1 | |
| E637 SCHEMBL27635951 | 0.79 | KDM4E (0.53) | KDM4ELMNAAPPFTOMMP1 | |
| E637 SCHEMBL6657728 | 0.79 | KDM4E (0.53) | KDM4ELMNAAPPFTOMMP1 | |
| SCHEMBL9625161 | 0.78 | KDM4E (0.52) | KDM4ELMNAAPPFTOMMP1 | |
| SCHEMBL9700079 | 0.78 | KDM4E (0.47) | KDM4ELMNAAPPFTOMMP1 | |
| SCHEMBL3316478 | 0.76 | KDM4E (0.46) | KDM4ELMNAAPPFTOMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109438405-B | Synthetic method of 3- (benzyloxy) -4-oxo-4H-pyran-2-carboxylic acid | 广东莱佛士制药技术有限公司 | 2023-04-07 | — | — | CN | claimed |
| CN-111320598-B | Preparation method of hydroxypyrone compound | 广东东阳光药业有限公司 | 2022-04-26 | — | — | CN | claimed |
| CN-111320598-A | Preparation method of hydroxypyrone compound | 广东东阳光药业有限公司 | 2020-06-23 | — | — | CN | claimed |
| JP-61197506-A | — | — | None | — | — | JP | disclosed |
| CN-118702662-A | Green technology for synthesizing 4-methyl-2H-pyran-2, 6 (3H) -dione | 无锡小荷智化科技有限公司 | 2024-09-27 | — | — | CN | disclosed |
| CN-109438405-B | Synthetic method of 3- (benzyloxy) -4-oxo-4H-pyran-2-carboxylic acid | 广东莱佛士制药技术有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-111320598-B | Preparation method of hydroxypyrone compound | 广东东阳光药业有限公司 | 2022-04-26 | — | — | CN | disclosed |
| CN-111320598-B | Preparation method of hydroxypyrone compound | 广东东阳光药业有限公司 | 2022-04-26 | — | — | CN | disclosed |
| CN-111606879-A | Method for preparing 2-hydroxymethyl-3-alkoxy-4H-pyran-4-ketone by one-pot method | 安徽金禾实业股份有限公司 | 2020-09-01 | — | — | CN | disclosed |
| WO-2020132820-A1 | SYNTHESIS METHOD FOR 3-(BENZYLOXY)-4-OXO-4H-PYRAN-2-CARBOXYLIC ACID | 广东莱佛士制药技术有限公司 | 2020-07-02 | — | — | WO | disclosed |
| WO-2020132820-A1 | SYNTHESIS METHOD FOR 3-(BENZYLOXY)-4-OXO-4H-PYRAN-2-CARBOXYLIC ACID | 广东莱佛士制药技术有限公司 | 2020-07-02 | — | — | WO | disclosed |
| US-20020068758-A1 | Novel orally active iron (III) chelators | BTG INTERNATIONAL LIMITED. | 2002-06-06 | — | — | US | disclosed |
| US-6335353-B1 | 3-HYDROXYPYRIDIN-4-ONE DERIVATIVE; IRON DEFICIENCY ANEMIA AND THALASSEMIA TREATMENT | BTG INTERNATIONAL LIMITED (GB) | 2002-01-01 | — | — | US | disclosed |
| EP-0984934-A1 | NOVEL ORALLY ACTIVE IRON (III) CHELATORS | BTG INTERNATIONAL LIMITED (Company No. 2664412) (GB) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998054138-A1 | NOVEL ORALLY ACTIVE IRON (III) CHELATORS | BTG INTERNATIONAL LIMITED (GB) | 1998-12-03 | — | — | WO | disclosed |
| WO-1992012131-A1 | 3-HYDROXYPYRIDIN-4-ONE DERIVATIVES AS PHARMACEUTICAL COMPOSITIONS | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1992-07-23 | — | — | WO | disclosed |
| EP-0494754-A1 | 3-hydroxypyridin-4-one derivatives as pharmaceutical compositions | BRITISH TECHNOLOGY GROUP LTD (GB) | 1992-07-15 | — | — | EP | disclosed |
| JP-S61197506-A | PREVENTION OF COLOR-BLACKENING OF LIVING BODIES WITH GAMMA-PYRONE DERIVATIVE | YAKURIGAKU CHUO KENKYUSHO:KK | 1986-09-01 | — | — | JP | disclosed |
| US-4219483-A | 4-Pyrone prostaglandin antagonists | PFIZER INC. (US) | 1980-08-26 | — | — | US | disclosed |
| US-4132847-A | 4-Pyrone prostaglandin antagonists | PFIZER INC. (US) | 1979-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020068758-A1 | Novel orally active iron (III) chelators | HAMP, HRH2, GRHPR | KDM4E 1012/4885LMNA 2634/4885APP 4051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.