Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.64 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10875605 | 0.90 | TOP2A (0.56) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL10875166 | 0.90 | ALDH1A1 (0.62) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL9773808 | 0.89 | KCNH2 (0.61) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL10876273 | 0.87 | TOP2A (0.48) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL9519028 | 0.84 | TOP2A (0.64) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL10679827 | 0.83 | MEN1 (0.61) | TOP2ATOP2BKCNH2POLBMEN1 | |
| SCHEMBL10849002 | 0.82 | LMNA (0.66) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL10850221 | 0.82 | LMNA (0.65) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL9270913 | 0.81 | KCNH2 (0.53) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL10881020 | 0.81 | KDM4E (0.56) | TOP2ATOP2BALDH1A1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098913-A | Bactericides for grampositive bacteria | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1992-03-24 | — | — | US | disclosed |
| EP-0203488-A2 | 7-Azolyl-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinoline carboxylic acids and 1,8-naphthyridine carboxylic acids, process for their preparation and bactericidal agents containing them | BAYER AG (DE) | 1986-12-03 | — | — | EP | disclosed |