Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CCNK | O75909 | 1/20 | 0.33 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.31 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9699455 | 0.76 | KCNJ5 (0.35) | MAPK14TMEM97SIGMAR1MEN1KMT2A | |
| SCHEMBL17769477 | 0.73 | CA2 (0.43) | MAPK14MEN1KMT2ACCNKCDK12 | |
| SCHEMBL17768052 | 0.73 | CA2 (0.43) | MAPK14MEN1KMT2ACCNKCDK12 | |
| SCHEMBL17768055 | 0.73 | CA2 (0.43) | MAPK14MEN1KMT2ACCNKCDK12 | |
| SCHEMBL11156125 | 0.73 | CHRNB2 (0.43) | MAPK14TMEM97SIGMAR1MEN1KMT2A | |
| SCHEMBL22710272 | 0.69 | TDP1 (0.59) | MAPK14TMEM97SIGMAR1MEN1KMT2A | |
| SCHEMBL1817280 | 0.67 | CA2 (0.43) | MAPK14TMEM97SIGMAR1MEN1KMT2A | |
| SCHEMBL30918574 | 0.67 | CA2 (0.43) | MAPK14TMEM97SIGMAR1MEN1KMT2A | |
| SCHEMBL1817279 | 0.67 | CA2 (0.43) | MAPK14TMEM97SIGMAR1MEN1KMT2A | |
| SCHEMBL9981632 | 0.67 | CA2 (0.43) | MAPK14TMEM97SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5082939-A | Pyridazine derivatives | I.S.F. SOCIETA PER AZIONI (IT) | 1992-01-21 | — | — | US | disclosed |
| US-4873328-A | Process for preparing alkoxyalkylidenehydrazinopyridazine derivatives | I.S.F. SOCIETA PER AZIONI (IT) | 1989-10-10 | — | — | US | disclosed |
| EP-0274409-A2 | Process for preparing alkoxyalkyl-idenehydrazinopyridazine derivatives | I.S.F. Socièta per Azioni (IT) | 1988-07-13 | — | — | EP | disclosed |