Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCE | Q02156 | 3/20 | 0.47 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.47 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MYLK | Q15746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9699529 | 0.83 | HMGB1 (0.45) | HMGB1CXCL12PTPN1LCKALDH1A1 | |
| SCHEMBL28544278 | 0.83 | AKR1C2 (0.53) | HMGB1CXCL12PTPN1ALDH1A1MEN1 | |
| SCHEMBL6618063 | 0.82 | PPARA (0.55) | PTPN1LCKALDH1A1MEN1MAPT | |
| SCHEMBL9701888 | 0.81 | HMGB1 (0.44) | HMGB1CXCL12PTPN1LCKALDH1A1 | |
| SCHEMBL24614011 | 0.80 | PRKCE (0.54) | PRKCEALDH1A1MYLKMEN1PRKCG | |
| SCHEMBL9699535 | 0.80 | PPARA (0.43) | HMGB1CXCL12PTPN1LCKALDH1A1 | |
| SCHEMBL9700687 | 0.79 | HMGB1 (0.52) | HMGB1CXCL12PTPN1LCKALDH1A1 | |
| SCHEMBL28543806 | 0.79 | KLKB1 (0.65) | PTPN1LCKKDM4CALDH1A1MEN1 | |
| SCHEMBL22529565 | 0.76 | MCL1 (0.53) | HMGB1CXCL12PTPN1LCKKLKB1 | |
| SCHEMBL18341497 | 0.76 | NPC1 (0.53) | ALDH1A1MAPTRECQLKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166060-A | Prepared by the action of 2,3-dihydroxybenzoate-3,4-dioxygenase on 2,3-dihydroxybenzoic acid | CELGENE CORPORATION (US) | 1992-11-24 | — | — | US | claimed |
| EP-0390102-A2 | Process for the preparation of pyridine-2,3-dicarboxylic acids | CELGENE CORPORATION (US) | 1990-10-03 | — | — | EP | claimed |
| US-5166060-A | Prepared by the action of 2,3-dihydroxybenzoate-3,4-dioxygenase on 2,3-dihydroxybenzoic acid | CELGENE CORPORATION (US) | 1992-11-24 | — | — | US | disclosed |
| EP-0390102-A2 | Process for the preparation of pyridine-2,3-dicarboxylic acids | CELGENE CORPORATION (US) | 1990-10-03 | — | — | EP | disclosed |