Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGB1 | P09429 | 1/20 | 0.44 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.39 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.39 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.39 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA7 | P43166 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27798081 | 0.84 | PPARA (0.51) | PTPN1ALDH1A1LCKKLKB1CTSB | |
| SCHEMBL9700693 | 0.81 | PRKCE (0.47) | HMGB1CXCL12PTPN1ALDH1A1LCK | |
| SCHEMBL10447107 | 0.81 | KLKB1 (0.59) | ALDH1A1LCKKLKB1CTSBMMP9 | |
| SCHEMBL9699529 | 0.79 | HMGB1 (0.45) | HMGB1CXCL12PTPN1ALDH1A1LCK | |
| SCHEMBL27641727 | 0.78 | AKR1C2 (0.52) | HMGB1CXCL12PTPN1LCKKLKB1 | |
| SCHEMBL9699535 | 0.76 | PPARA (0.43) | HMGB1CXCL12PTPN1ALDH1A1LCK | |
| SCHEMBL9700687 | 0.75 | HMGB1 (0.52) | HMGB1CXCL12PTPN1ALDH1A1LCK | |
| SCHEMBL23471260 | 0.74 | MRGPRX4 (0.41) | CA12CA1CA2CA7CA9 | |
| SCHEMBL27811020 | 0.73 | CA12 (0.50) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL15523841 | 0.73 | GRIN2D (0.48) | HMGB1CXCL12PTPN1LCKKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166060-A | Prepared by the action of 2,3-dihydroxybenzoate-3,4-dioxygenase on 2,3-dihydroxybenzoic acid | CELGENE CORPORATION (US) | 1992-11-24 | — | — | US | claimed |
| US-5166060-A | Prepared by the action of 2,3-dihydroxybenzoate-3,4-dioxygenase on 2,3-dihydroxybenzoic acid | CELGENE CORPORATION (US) | 1992-11-24 | — | — | US | disclosed |
| EP-0390102-A2 | Process for the preparation of pyridine-2,3-dicarboxylic acids | CELGENE CORPORATION (US) | 1990-10-03 | — | — | EP | disclosed |