Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 13/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | TNKS | O95271 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2402197 | 0.90 | PPARG (0.59) | PPARGNFE2L2LMNAALDH1A1HTT | |
| SCHEMBL7194001 | 0.89 | PPARG (0.58) | PPARGNFE2L2LMNAALDH1A1HTT | |
| SCHEMBL7217996 | 0.87 | PPARG (0.41) | PPARGNFE2L2LMNAHDAC3TNKS | |
| Styrene SCHEMBL27563017 | 0.85 | PPARG (0.54) | PPARGNFE2L2LMNAALDH1A1HTT | |
| SCHEMBL7211855 | 0.84 | PPARG (0.47) | PPARGNFE2L2LMNAHDAC3TNKS | |
| SCHEMBL7213114 | 0.81 | PPARG (0.42) | PPARGNFE2L2LMNAHCAR2ALDH1A1 | |
| SCHEMBL1462403 | 0.79 | HCAR2 (0.52) | PPARGNFE2L2LMNAHDAC3TNKS | |
| SCHEMBL3857849 | 0.79 | HCAR2 (0.52) | PPARGNFE2L2LMNAHDAC3TNKS | |
| SCHEMBL28358859 | 0.78 | PPARG (0.50) | PPARGNFE2L2LMNAHDAC3TNKS | |
| SCHEMBL28358616 | 0.78 | PPARG (0.50) | PPARGNFE2L2LMNAHDAC3TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5171459-A | Scale deposition inhibitor | NALCO CHEMICAL COMPANY (US) | 1992-12-15 | — | — | US | disclosed |