Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 2/20 | 0.59 |
| ▸ | BLM | P54132 | 5/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.57 |
| ▸ | ADRB3 | P13945 | 7/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.56 |
| ▸ | RECQL | P46063 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | APEX1 | P27695 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7154449 | 1.00 | NFKB1 (0.59) | NFKB1BLMPMP22ADRB3ADRB2 | |
| SCHEMBL13589394 | 0.85 | CA12 (0.54) | NFKB1ADRB3ADRB2ADRB1ADRA1D | |
| SCHEMBL29217760 | 0.81 | KDM4E (0.64) | NFKB1BLMPMP22ADRB3ADRB2 | |
| SCHEMBL9135589 | 0.81 | ADRB2 (0.62) | NFKB1BLMPMP22ADRB3ADRB2 | |
| SCHEMBL12208227 | 0.81 | CA12 (0.61) | ADRB3ADRB2ADRB1ADRA1DMAPT | |
| SCHEMBL30883921 | 0.81 | ADRB2 (0.62) | NFKB1BLMPMP22ADRB3ADRB2 | |
| SCHEMBL6075622 | 0.81 | ADRB2 (0.62) | NFKB1BLMPMP22ADRB3ADRB2 | |
| SCHEMBL9755160 | 0.80 | CA12 (0.65) | ADRB3ADRB2ADRB1ADRA1DMAPT | |
| SCHEMBL2585166 | 0.80 | ADRB2 (0.59) | NFKB1PMP22ADRB3ADRB2ADRB1 | |
| SCHEMBL11263513 | 0.80 | CA12 (0.59) | ADRB3ADRB2ADRB1ADRA1DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992005143-A1 | ANTI-HYPERTENSIVE TETRALINS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-04-02 | — | — | WO | disclosed |