Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.52 |
| ▸ | PLAU | P00749 | 2/20 | 0.52 |
| ▸ | NCF1 | P14598 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | COMT | P21964 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31418282 | 0.82 | MAPT (0.45) | KDM4EKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL3112677 | 0.81 | KMT2A (0.64) | METAP2PLAUNCF1KDM4EKMT2A | |
| SCHEMBL463283 | 0.81 | PLAU (0.55) | METAP2PLAUNCF1KDM4EKMT2A | |
| SCHEMBL30318916 | 0.79 | KMT2A (0.62) | METAP2PLAUNCF1KDM4EKMT2A | |
| Methane SCHEMBL9370413 | 0.79 | KMT2A (0.62) | METAP2PLAUNCF1KDM4EKMT2A | |
| SCHEMBL28153007 | 0.78 | KMT2A (0.60) | METAP2PLAUNCF1KDM4EKMT2A | |
| SCHEMBL15845269 | 0.77 | KMT2A (0.55) | METAP2PLAUNCF1KDM4EKMT2A | |
| SCHEMBL15117515 | 0.76 | KDM4E (0.50) | METAP2PLAUNCF1KDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL28213132 | 0.76 | KMT2A (0.58) | METAP2PLAUNCF1KDM4EKMT2A | |
| SCHEMBL28203737 | 0.76 | PLAU (0.46) | METAP2PLAUNCF1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1681791-B | 8-hydroxy quinoline derivatives | PRANA BIOTECHNOLOGY LTD | 2013-03-27 | — | — | CN | disclosed |
| CN-1681791-A | 8-hydroxy quinoline derivatives | PRANA BIOTECHNOLOGY LTD (AU) | 2005-10-12 | — | — | CN | disclosed |
| US-5118499-A | Quinoline polymers, their chelates and process of preparation and use | THEODOROPULOS SPYROS (US) | 1992-06-02 | — | — | US | disclosed |