Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | PREP | P48147 | 10/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9702386 | 0.81 | PREP (0.46) | PREPNPC1RAB9ASMN1; SMN2PARP1 | |
| SCHEMBL9701702 | 0.80 | PREP (0.67) | DPP4PREP | |
| SCHEMBL9702413 | 0.78 | PREP (0.45) | PREPSMN1; SMN2 | |
| SCHEMBL7400021 | 0.78 | NPC1 (0.52) | PREPNPC1RAB9ASMN1; SMN2PARP1 | |
| SCHEMBL6204670 | 0.73 | SIGMAR1 (0.49) | — | |
| SCHEMBL11192909 | 0.71 | PREP (0.52) | DPP4PREPNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6255834 | 0.71 | NPC1 (0.47) | PREPNPC1RAB9ASMN1; SMN2PARP1 | |
| SCHEMBL1437419 | 0.70 | PREP (0.69) | DPP4PREP | |
| SCHEMBL1437422 | 0.70 | PREP (0.69) | DPP4PREP | |
| SCHEMBL943473 | 0.70 | PREP (0.69) | DPP4PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5118811-A | Treatment and prevention of dementia and amnesia | JAPAN TOBACCO INC. (JP) | 1992-06-02 | — | — | US | claimed |
| EP-0419683-A1 | NEW AMINO ACID DERIVATIVES HAVING PROLYLENDOPEPTIDASE INHIBITOR ACTIVITY | Japan Tobacco Inc. (JP) | 1991-04-03 | — | — | EP | claimed |
| US-5118811-A | Treatment and prevention of dementia and amnesia | JAPAN TOBACCO INC. (JP) | 1992-06-02 | — | — | US | disclosed |
| EP-0419683-A1 | NEW AMINO ACID DERIVATIVES HAVING PROLYLENDOPEPTIDASE INHIBITOR ACTIVITY | Japan Tobacco Inc. (JP) | 1991-04-03 | — | — | EP | disclosed |