Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | CDK4 | P11802 | 4/20 | 0.56 |
| ▸ | CCND1 | P24385 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1520197 | 0.85 | HTR2A (0.62) | LMNAHTR2AHTR2CCDK4CCND1 | |
| SCHEMBL7349228 | 0.78 | LMNA (1.00) | LMNAHTR2AHTR2CCDK4CCND1 | |
| SCHEMBL11366447 | 0.74 | CDK4 (1.00) | LMNAHTR2AHTR2CCDK4CCND1 | |
| SCHEMBL1519806 | 0.74 | KMT2A (0.71) | LMNACDK4CCND1KMT2AMAPK1 | |
| SCHEMBL29955957 | 0.74 | KMT2A (0.71) | LMNACDK4CCND1KMT2AMAPK1 | |
| SCHEMBL4060777 | 0.74 | HTR2C (1.00) | LMNAHTR2AHTR2CCDK4CCND1 | |
| SCHEMBL5324291 | 0.73 | LMNA (0.59) | LMNAHTR2AHTR2CCDK4CCND1 | |
| Fumaric Acid SCHEMBL23927822 | 0.72 | HTR2C (0.75) | LMNAHTR2AHTR2CCDK4CCND1 | |
| Fumaric Acid SCHEMBL29435341 | 0.72 | HTR2C (0.75) | LMNAHTR2AHTR2CCDK4CCND1 | |
| SCHEMBL29684637 | 0.72 | LMNA (0.73) | LMNAHTR2AHTR2CCDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132319-A | Antiasthmatic, antiinflammatory, antiallergen and cytoprotective agents | MERCK FROSST CANADA, INC. (CA) | 1992-07-21 | — | — | US | disclosed |