Sugi Predict

Sugi Predict / Compounds / SCHEMBL970205

SCHEMBL970205

SCHEMBL970205

Cc1cc(C)nc(N2CCOCC2)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 4/20 0.67
▸ CRHBP P24387 2/20 0.65
▸ CRHR2 Q13324 2/20 0.65
▸ NPSR1 Q6W5P4 1/20 0.58
▸ HRH4 Q9H3N8 1/20 0.58
▸ SMN1; SMN2 Q16637 3/20 0.54
▸ MAPT P10636 3/20 0.51
▸ ALDH1A1 P00352 4/20 0.50
▸ HTT P42858 3/20 0.50
▸ GAA P10253 2/20 0.50
▸ HPGD P15428 2/20 0.50
▸ TSHR P16473 2/20 0.50
▸ KDM4E B2RXH2 1/20 0.50
▸ PKM P14618 1/20 0.50
▸ PIK3CB P42338 1/20 0.50
▸ MEN1 O00255 2/20 0.48
▸ CYP1A2 P05177 1/20 0.47
▸ CYP2D6 P10635 1/20 0.47
▸ ALOX15 P16050 1/20 0.47
▸ CASP1 P29466 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12110309 0.90 KMT2A (0.62) KMT2ACRHBPCRHR2NPSR1HRH4
SCHEMBL23299953 0.84 KMT2A (0.56) KMT2ACRHBPCRHR2NPSR1HRH4
SCHEMBL12110419 0.84 KMT2A (0.65) KMT2ACRHBPCRHR2NPSR1HRH4
SCHEMBL12250749 0.82 CRHBP (0.59) KMT2ACRHBPCRHR2NPSR1HRH4
SCHEMBL913213 0.82 KMT2A (0.63) KMT2ACRHBPCRHR2NPSR1HRH4
SCHEMBL22121021 0.82 CRHBP (0.61) KMT2ACRHBPCRHR2NPSR1HRH4
SCHEMBL22488001 0.82 KMT2A (0.54) KMT2ACRHBPCRHR2NPSR1HRH4
SCHEMBL20782930 0.82 KMT2A (0.63) KMT2ACRHBPCRHR2NPSR1HRH4
SCHEMBL18282242 0.82 KMT2A (0.63) KMT2ACRHBPCRHR2NPSR1HRH4
SCHEMBL13173926 0.82 CYP1A2 (0.61) KMT2ACRHBPCRHR2NPSR1HRH4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11407737-B2 Inhibitors of RAF kinases KINNATE BIOPHARMA INC. (US) 2022-08-09 — — US disclosed
WO-2021081375-A1 INHIBITORS OF RAF KINASES KINNATE BIOPHARMA INC. (US) 2021-04-29 — — WO disclosed
WO-2019038384-A1 AZAINDOLYLPYRIDONE AND DIAZAINDOLYLPYRIDONE COMPOUNDS SPRINT BIOSCIENCE AB (SE) 2019-02-28 — — WO disclosed
US-20170198006-A1 PRMT5 INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2017-07-13 — — US disclosed
WO-2015200680-A2 PRMT5 INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2015-12-30 — — WO disclosed
US-8921361-B2 Triazine, pyrimidine and pyridine analogs and their use as therapeutic agents and diagnostic probes UNIVERSITY OF BASEL (CH) 2014-12-30 — — US disclosed
CN-102276523-B Substituted pyridine derivatives LUNDBECK CO LTD H 2014-12-10 — — CN disclosed
EP-2298766-B1 Pharmaceutical formulations comrpising a substituted pyridine derivative LUNDBECK & CO AS H (DK) 2013-09-18 — — EP disclosed
US-8299071-B2 Substituted pyridine derivatives H. LUNDBECK A/S (DK) 2012-10-30 — — US disclosed
US-20120258967-A1 PI3 KINASE INHIBITORS AND USES THEREOF AVILA THERAPEUTICS, INC. (US) 2012-10-11 — — US disclosed
CN-102516165-A Substituted pyridine derivatives LUNDBECK & CO AS H 2012-06-27 — — CN disclosed
CN-102276523-A Substituted pyridine derivatives LUNDBECK CO LTD H 2011-12-14 — — CN disclosed
US-20110275762-A1 TRIAZINE, PYRIMIDINE AND PYRIDINE ANALOGS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES UNIVERSITY OF BASEL (CH) 2011-11-10 — — US disclosed
EP-2298766-A1 Substituted pyridine derivatives H. Lundbeck A/S (DK) 2011-03-23 — — EP disclosed
US-20110003811-A1 SUBSITUTED PYRIDINE DERIVATIVES H. LUNDBECK A/S (DK) 2011-01-06 — — US disclosed
US-7812020-B2 Substituted pyridine derivatives H. LUNDBECK A/S (DK) 2010-10-12 — — US disclosed
US-20080318953-A1 Substituted Pyridine Derivatives H. LUNDBECK A/S (DK) 2008-12-25 — — US disclosed
CN-101133053-A Substituted pyridine derivatives LUNDBECK & CO AS H (DK) 2008-02-27 — — CN disclosed
EP-1861394-A1 SUBSTITUTED PYRIDINE DERIVATIVES H.Lundbeck A/S (DK) 2007-12-05 — — EP disclosed
WO-2006092143-A1 SUBSTITUTED PYRIDINE DERIVATIVES H. LUNDBECK A/S (DK) 2006-09-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275762-A1 TRIAZINE, PYRIMIDINE AND PYRIDINE ANALOGS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES MTOR, PIK3CA, PIK3CD KMT2A 4567/4885CRHBP 4023/4885CRHR2 2333/4885
US-11407737-B2 Inhibitors of RAF kinases BRAF, RAF1, ARAF KMT2A 1631/4885CRHBP 4714/4885CRHR2 4419/4885
US-20080318953-A1 Substituted Pyridine Derivatives KCNQ2, KCNQ1, KCNQ5 KMT2A 617/4885CRHBP 4149/4885CRHR2 3657/4885
US-20120258967-A1 PI3 KINASE INHIBITORS AND USES THEREOF PIK3CA, PIK3CB, PIK3C2B KMT2A 2741/4885CRHBP 4538/4885CRHR2 4566/4885
US-20170198006-A1 PRMT5 INHIBITORS AND USES THEREOF PRMT5, PRMT1, PRMT6 KMT2A 60/4885CRHBP 2938/4885CRHR2 3601/4885
US-20110003811-A1 SUBSITUTED PYRIDINE DERIVATIVES KCNQ2, KCNQ1, KCNQ5 KMT2A 637/4885CRHBP 3591/4885CRHR2 2693/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.