Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 4/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | SNCA | P37840 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30575395 | 0.87 | ALDH1A1 (0.73) | CYP3A4ALDH1A1HSD17B10HPGDESR1 | |
| SCHEMBL593005 | 0.87 | ALDH1A1 (0.73) | CYP3A4ALDH1A1HSD17B10HPGDESR1 | |
| SCHEMBL9702971 | 0.85 | RAB9A (0.61) | ALDH1A1ESR2TDP1RECQLTHRB | |
| Hydroquinone SCHEMBL11583598 | 0.84 | ALDH1A1 (0.81) | CYP3A4ALDH1A1HSD17B10HPGDESR1 | |
| SCHEMBL9703852 | 0.84 | ALDH1A1 (0.49) | CYP3A4ALDH1A1HSD17B10HPGDALOX15 | |
| SCHEMBL10419897 | 0.84 | ALDH1A1 (0.53) | CYP3A4ALDH1A1HSD17B10HPGDALOX15 | |
| SCHEMBL9703877 | 0.84 | ALDH1A1 (0.47) | CYP3A4ALDH1A1HSD17B10HPGDESR1 | |
| SCHEMBL9703849 | 0.81 | MAPT (0.55) | CYP3A4ALDH1A1ESR2ALOX15HIF1A | |
| SCHEMBL9702536 | 0.81 | CYP3A4 (0.46) | CYP3A4ALDH1A1HSD17B10HPGDALOX15 | |
| SCHEMBL306231 | 0.80 | ALDH1A1 (0.57) | CYP3A4ALDH1A1HSD17B10HPGDESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221677-B1 | P-AMINOPHENOLS, DERIVATIVES THEREOF AND USE FOR MANUFACTURE OF A MEDICAMENT | E.R. Squibb & Sons, Inc. (US) | 1992-09-09 | — | — | EP | disclosed |
| US-4910208-A | Skin disorders, antiinflammatory agent | E. R. SQUIBB & SONS, INC. (US) | 1990-03-20 | — | — | US | disclosed |
| US-4814454-A | ANTIALLERGENS, ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1989-03-21 | — | — | US | disclosed |
| EP-0221677-A2 | p-Aminophenols, derivatives thereof and use for manufacture of a medicament | E.R. Squibb & Sons, Inc. (US) | 1987-05-13 | — | — | EP | disclosed |