SCHEMBL9702220

SCHEMBL9702220

COc1c(C)cc(CCCCCCN2CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC2)cc1C

nearest known ligand 0.53

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 10/20 0.53
CASP5 P51878 10/20 0.53
CASP4 P49662 8/20 0.53
HTR1A P08908 3/20 0.42
KMT5A Q9NQR1 5/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9688215 0.96 CASP1 (0.55) CASP1CASP5CASP4HTR1AKMT5A
SCHEMBL9688140 0.91 CASP1 (0.62) CASP1CASP5CASP4
Hydrochloric Acid SCHEMBL10367476 0.90 CASP1 (0.61) CASP1CASP5CASP4
SCHEMBL9130732 0.82 CASP1 (0.56) CASP1CASP5CASP4
SCHEMBL9702314 0.79 CASP1 (0.46) CASP1CASP5CASP4HTR1AKMT5A
SCHEMBL9688138 0.77 CASP1 (0.58) CASP1CASP5CASP4
SCHEMBL9689097 0.77 CASP1 (0.58) CASP1CASP5CASP4
Hydrochloric Acid SCHEMBL9688259 0.76 CASP1 (0.56) CASP1CASP5CASP4
SCHEMBL9688206 0.76 CASP1 (0.58) CASP1CASP5CASP4KMT5A
SCHEMBL9689535 0.75 CASP1 (0.58) CASP1CASP5CASP4KMT5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5120843-A Nervous system disorders UPJOHN (US) 1992-06-09 US disclosed