Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 7/20 | 0.57 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.57 |
| ▸ | AGT | P01019 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9701476 | 0.87 | AGTR1 (0.54) | AGTR1AGTR2AGTPPARG | |
| SCHEMBL9851487 | 0.84 | AGTR1 (0.63) | AGTR1AGTR2AGTPPARG | |
| SCHEMBL9259102 | 0.84 | AGTR1 (0.54) | AGTR1AGTR2AGT | |
| SCHEMBL9851410 | 0.82 | AGTR1 (0.64) | AGTR1AGTR2AGTPPARG | |
| SCHEMBL9854421 | 0.81 | AGTR1 (0.62) | AGTR1AGTR2AGT | |
| SCHEMBL9263837 | 0.81 | AGT (0.57) | AGTR1AGTR2AGT | |
| SCHEMBL9851456 | 0.81 | AGTR1 (0.52) | AGTR1AGTR2AGTP2RX7 | |
| SCHEMBL9851481 | 0.81 | AGTR1 (0.54) | AGTR1AGTR2AGT | |
| SCHEMBL7012281 | 0.79 | AGTR1 (0.53) | AGTR1AGTR2AGTPPARG | |
| SCHEMBL9265478 | 0.79 | AGTR1 (0.56) | AGTR1AGTR2AGTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497516-A1 | Substituted pyrrolo-fused 6-membered heterocycles as angiotensin II antagonists | MERCK & CO. INC. (US) | 1992-08-05 | — | — | EP | disclosed |
| US-5124335-A | Hypotensive agents, antiglaucoma agents | MERCK & CO., INC. (US) | 1992-06-23 | — | — | US | disclosed |