Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.52 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.52 |
| ▸ | AGT | P01019 | 2/20 | 0.45 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | P62805 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9851481 | 0.90 | AGTR1 (0.54) | AGTR1AGTR2AGTBRD4POLB | |
| SCHEMBL9851487 | 0.88 | AGTR1 (0.63) | AGTR1AGTR2AGTPDE4APDE4B | |
| SCHEMBL9854421 | 0.87 | AGTR1 (0.62) | AGTR1AGTR2AGTENPP2 | |
| SCHEMBL9851445 | 0.86 | AGTR1 (0.53) | AGTR1AGTR2AGTBRD4P2RX7 | |
| SCHEMBL9402014 | 0.86 | AGTR1 (0.57) | AGTR1AGTR2AGTPOLBLMNA | |
| SCHEMBL9702222 | 0.81 | AGTR1 (0.57) | AGTR1AGTR2AGTP2RX7 | |
| SCHEMBL9851420 | 0.80 | AGTR1 (0.55) | AGTR1AGTR2AGTBRD4P2RX7 | |
| SCHEMBL1413257 | 0.79 | AGTR1 (0.53) | AGTR1AGTR2AGTLMNATP53 | |
| SCHEMBL9402064 | 0.78 | AGTR1 (0.55) | AGTR1AGTR2AGTLMNA | |
| SCHEMBL9851410 | 0.78 | AGTR1 (0.64) | AGTR1AGTR2AGT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0434038-A1 | Fused imidazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-06-26 | — | — | EP | disclosed |