Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.42 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430448 | 0.84 | PPARD (0.66) | LCKPPARDZDHHC20ZDHHC2TDP1 | |
| SCHEMBL97405 | 0.81 | LDHA (0.38) | LCKPPARDZDHHC20ZDHHC2HDAC1 | |
| SCHEMBL4473150 | 0.80 | ZDHHC7 (0.46) | LCKPPARDZDHHC20ZDHHC2HDAC1 | |
| SCHEMBL6266183 | 0.79 | LCK (0.48) | LCKPPARDZDHHC20ZDHHC2ZDHHC7 | |
| SCHEMBL6603806 | 0.77 | GAA (0.54) | LCKPPARDZDHHC20ZDHHC2ZDHHC7 | |
| SCHEMBL29084203 | 0.76 | HDAC1 (0.56) | HDAC1HDAC2CHRM1AKR1A1CHRM3 | |
| SCHEMBL1732518 | 0.75 | — | — | |
| SCHEMBL287910 | 0.75 | — | — | |
| SCHEMBL1732573 | 0.75 | — | — | |
| Dimethylamine SCHEMBL28781213 | 0.74 | LCK (0.59) | LCKPPARDZDHHC20ZDHHC2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021057014-A1 | KLUYVEROMYCES MARXIANUS ALDO-KETO REDUCTASE KMAKR MUTANT AND APPLICATION THEREOF | 浙江工业大学 | 2021-04-01 | — | — | WO | disclosed |
| US-7872032-B2 | 1, 3, 4-oxadiazol-2-ones as PPAR delta modulators and their use thereof | AVENTIS PARMACEUTICALS INC. (US) | 2011-01-18 | — | — | US | disclosed |
| US-7638539-B2 | 1, 3, 4-oxadiazol-2-ones as peroxisome-proliferator activated receptor delta modulators and their use in the treatment of neurological and metabolic disease | AVENTIS PHARMACEUTICALS INC. (US) | 2009-12-29 | — | — | US | disclosed |
| US-20090275621-A1 | 1, 3, 4-OXADIAZOL-2-ONES AS PPAR DELTA MODULATORS AND THEIR USE THEREOF | AVENTIS PHARMACEUTICALS INC. (US) | 2009-11-05 | — | — | US | disclosed |
| EP-1781648-A2 | 1,3,4-OXADIAZOL-2-ONES AS PPAR DELTA MODULATORS | Aventis Pharmaceuticals Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| US-20070099964-A1 | 1, 3, 4-OXADIAZOL-2-ONES AS PEROXISOME-PROLIFERATOR ACTIVATED RECEPTOR DELTA MODULATORS AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL AND METABOLIC DISEASE | AVENTIS PHARMACEUTICALS INC. (US) | 2007-05-03 | — | — | US | disclosed |
| WO-2005097763-A2 | 1,3,4-OXADIAZOL-2-ONES AS PPAR DELTA | AVENTIS PHARMACEUTICALS INC. (US) | 2005-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275621-A1 | 1, 3, 4-OXADIAZOL-2-ONES AS PPAR DELTA MODULATORS AND THEIR USE THEREOF | PPARD, PPARA, PPARG | LCK 2020/4885PPARD 1/4885ZDHHC20 512/4885 |
| US-20070099964-A1 | 1, 3, 4-OXADIAZOL-2-ONES AS PEROXISOME-PROLIFERATOR ACTIVATED RECEPTOR DELTA MODULATORS AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL AND METABOLIC DISEASE | PPARD, PPARA, PPARG | LCK 2155/4885PPARD 1/4885ZDHHC20 893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.