Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.48 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.48 |
| ▸ | GABRR1 | P24046 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.32 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.31 |
| ▸ | KDM4A | O75164 | 2/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.31 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.31 |
| ▸ | TET3 | O43151 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.30 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.30 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL9394864 | 1.00 | GLRA1 (0.48) | GLRA1SLC6A9OR51E2GABRR1LMNA | |
| SCHEMBL3056738 | 0.87 | — | — | |
| SCHEMBL18902875 | 0.87 | — | — | |
| SCHEMBL158299 | 0.87 | — | — | |
| Succinic Acid SCHEMBL8578421 | 0.86 | LMNA (0.43) | OR51E2GABRR1LMNASMN1; SMN2SLC22A6 | |
| Serine SCHEMBL9395628 | 0.85 | ALOX15 (0.37) | GLRA1SLC6A9OR51E2GABRR1LMNA | |
| SCHEMBL8087904 | 0.85 | LMNA (0.33) | GABRR1LMNASMN1; SMN2SLC22A6 | |
| SCHEMBL31040601 | 0.85 | LMNA (0.33) | GABRR1LMNASMN1; SMN2SLC22A6 | |
| Ammonia Solution, Strong SCHEMBL27820138 | 0.85 | LMNA (0.33) | GABRR1LMNASMN1; SMN2SLC22A6 | |
| SCHEMBL2163096 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992012952-A1 | MALIC ACID DERIVATIVES AND COMPOSITIONS FOR THE TREATMENT OF PSORIASIS | DEXTER CHEMICAL CORPORATION (US) | 1992-08-06 | — | — | WO | disclosed |