Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.60 |
| ▸ | BRD4 | O60885 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.60 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | HTR2B | P41595 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.48 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6920081 | 0.87 | KDM4E (0.67) | HTR2CKDM4EADRB2BRD4ALDH1A1 | |
| SCHEMBL734917 | 0.85 | HTR2C (0.79) | HTR2CKDM4EADRB2BRD4ALDH1A1 | |
| SCHEMBL9703358 | 0.81 | KDM4E (0.56) | HTR2CKDM4EADRB2BRD4ALDH1A1 | |
| SCHEMBL27779740 | 0.81 | HTR2C (0.68) | HTR2CKDM4EADRB2BRD4ALDH1A1 | |
| SCHEMBL6344780 | 0.80 | SLC6A4 (0.56) | HSD11B1HTR2AADRA1DCCR2 | |
| SCHEMBL6342293 | 0.80 | HSD11B1 (0.58) | HTR2CHSD11B1HTR2AHTR2B | |
| SCHEMBL16801846 | 0.80 | KDM4E (0.74) | HTR2CKDM4EADRB2BRD4ALDH1A1 | |
| SCHEMBL5705116 | 0.79 | KDM4E (0.78) | HTR2CKDM4EADRB2BRD4ALDH1A1 | |
| SCHEMBL807343 | 0.79 | HTR2C (0.74) | HTR2CKDM4EADRB2BRD4ALDH1A1 | |
| SCHEMBL28594057 | 0.79 | HTR2C (0.74) | HTR2CKDM4EADRB2BRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992012977-A1 | SUBSTITUTED INDOLES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-08-06 | — | — | WO | disclosed |
| US-5124332-A | Dopaminergic agents, hypotensive agents | WARNER-LAMBERT COMPANY (US) | 1992-06-23 | — | — | US | disclosed |