Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SSTR1 | P30872 | 4/20 | 0.45 |
| ▸ | SSTR2 | P30874 | 4/20 | 0.45 |
| ▸ | SSTR4 | P31391 | 4/20 | 0.45 |
| ▸ | SSTR3 | P32745 | 4/20 | 0.45 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | CTSV | O60911 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.44 |
| ▸ | PRKCG | P05129 | 3/20 | 0.44 |
| ▸ | PRKCB | P05771 | 3/20 | 0.44 |
| ▸ | PRKCA | P17252 | 3/20 | 0.44 |
| ▸ | PRKCH | P24723 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9494966 | 1.00 | LOXL2 (0.62) | LOXL2HRH3MTNR1AMTNR1BKDM4E | |
| SCHEMBL8376332 | 0.98 | LOXL2 (0.65) | LOXL2HRH3MTNR1AMTNR1BKDM4E | |
| SCHEMBL1713962 | 0.93 | LOXL2 (0.67) | LOXL2HRH3MTNR1AMTNR1BKDM4E | |
| Hydrochloric Acid SCHEMBL27539522 | 0.91 | LOXL2 (0.65) | LOXL2HRH3MTNR1AMTNR1BKDM4E | |
| SCHEMBL653530 | 0.85 | LOXL2 (0.71) | LOXL2HRH3MTNR1AMTNR1BCHRNA7 | |
| SCHEMBL6860219 | 0.85 | LOXL2 (0.64) | LOXL2HRH3MTNR1AMTNR1BCHRNA7 | |
| Iodide SCHEMBL28690475 | 0.84 | LOXL2 (0.69) | LOXL2HRH3MTNR1AMTNR1BCHRNA7 | |
| Hydrochloric Acid SCHEMBL28686778 | 0.84 | LOXL2 (0.69) | LOXL2HRH3MTNR1AMTNR1BCHRNA7 | |
| Bromide SCHEMBL28679046 | 0.84 | LOXL2 (0.69) | LOXL2HRH3MTNR1AMTNR1BCHRNA7 | |
| SCHEMBL15642742 | 0.83 | LOXL2 (0.53) | LOXL2HRH3MTNR1AMTNR1BCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130308-A | Indole derivatives as anticarcinogenic agents | ASTA PHARMA (DE) | 1992-07-14 | — | — | US | disclosed |
| US-4992553-A | Treatment of hormone dependent tumors | ASTA PHARMA AKTIENGESELLSCHAFT (DE) | 1991-02-12 | — | — | US | disclosed |
| EP-0262498-B1 | DIAMINE PLATINUM (II) COMPLEX COMPOUNDS WITH A HYDROXY-SUBSTITUTED 2-PHENYL-INDOLE RING | ASTA Pharma Aktiengesellschaft (DE) | 1990-05-30 | — | — | EP | disclosed |
| EP-0262498-A2 | Diamine platinum (II) complex compounds with a hydroxy-substituted 2-phenyl-indole ring | ASTA Pharma Aktiengesellschaft (DE) | 1988-04-06 | — | — | EP | disclosed |