Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27539522 | 0.98 | LOXL2 (0.65) | LOXL2HRH3MTNR1AMTNR1BKDM4E | |
| SCHEMBL8376332 | 0.95 | LOXL2 (0.65) | LOXL2HRH3MTNR1AMTNR1BKDM4E | |
| SCHEMBL9703496 | 0.93 | LOXL2 (0.62) | LOXL2HRH3MTNR1AMTNR1BKDM4E | |
| SCHEMBL9494966 | 0.93 | LOXL2 (0.62) | LOXL2HRH3MTNR1AMTNR1BKDM4E | |
| SCHEMBL653530 | 0.89 | LOXL2 (0.71) | LOXL2HRH3MTNR1AMTNR1BAOC3 | |
| SCHEMBL6860219 | 0.88 | LOXL2 (0.64) | LOXL2HRH3MTNR1AMTNR1BAOC3 | |
| Hydrochloric Acid SCHEMBL28686778 | 0.87 | LOXL2 (0.69) | LOXL2HRH3MTNR1AMTNR1BAOC3 | |
| Iodide SCHEMBL28690475 | 0.87 | LOXL2 (0.69) | LOXL2HRH3MTNR1AMTNR1BAOC3 | |
| Bromide SCHEMBL28679046 | 0.87 | LOXL2 (0.69) | LOXL2HRH3MTNR1AMTNR1BAOC3 | |
| SCHEMBL31059889 | 0.84 | LOXL2 (0.69) | LOXL2HRH3MTNR1AMTNR1BAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957454-B1 | METHODS FOR SYNTHESIS OF 3-AMINO-1-ARYLPROPYL INDOLES | HOFFMANN LA ROCHE (CH) | 2011-07-20 | — | — | EP | claimed |
| US-7598399-B2 | Methods for synthesis of 3-amino-1-arylpropyl indoles | ROCHE PALO ALTO LLC (US) | 2009-10-06 | — | — | US | claimed |
| EP-1957454-A1 | METHODS FOR SYNTHESIS OF 3-AMINO-1-ARYLPROPYL INDOLES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-20 | — | — | EP | claimed |
| US-20070135647-A1 | Methods for synthesis of 3-amino-1-arylpropyl indoles | ROCHE PALO ALTO LLC | 2007-06-14 | — | — | US | claimed |
| WO-2007062994-A1 | METHODS FOR SYNTHESIS OF 3-AMINO-1-ARYLPROPYL INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | claimed |
| EP-3436017-B1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | MERCK SHARP & DOHME (US) | 2020-09-23 | — | — | EP | disclosed |
| US-10544147-B2 | Purine inhibitors of human phosphatidylinositol 3-kinase delta | MERCK SHARP & DOHME CORP. (US) | 2020-01-28 | — | — | US | disclosed |
| US-20190119278-A1 | Purine Inhibitors of Human Phosphatidylinositol 3-Kinase Delta | MERCK SHARP & DOHME CORP. (US) | 2019-04-25 | — | — | US | disclosed |
| EP-3436017-A1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | Merck Sharp & Dohme Corp. (US) | 2019-02-06 | — | — | EP | disclosed |
| WO-2017166104-A1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | MERCK SHARP & DOHME CORP. (US) | 2017-10-05 | — | — | WO | disclosed |
| WO-2017172507-A1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | MERCK SHARP & DOHME CORP. (US) | 2017-10-05 | — | — | WO | disclosed |
| US-8552032-B2 | Bicyclic derivatives useful as inhibitors of DPP-1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-10-08 | — | — | US | disclosed |
| EP-1070050-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-24 | — | — | EP | disclosed |
| EP-1068199-A2 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-17 | — | — | EP | disclosed |
| US-6150533-A | ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORP. (US) | 2000-11-21 | — | — | US | disclosed |
| CN-1269800-A | Tetrahydro Gamma-carbolines | JANSSON PHARMACEUTICAL N V (BE) | 2000-10-11 | — | — | CN | disclosed |
| US-6121307-A | SIDE EFFECT REDUCTION; ADMINISTERING TO TREAT DEPRESSION | AMERICAN HOME PRODUCTS CORP. (US) | 2000-09-19 | — | — | US | disclosed |
| US-5990094-A | SEROTONIN N-ACETYLTRANSFERASE INHIBITORS WHICH CAN SERVE AS BIOLOGICAL TOOLS THAT HELP REVEAL BIOLOGICAL FUNCTIONS FOR MELATONIN AND PINEAL SEROTONIN IN VIVO; ACETYL-COA N-ACETYL TRYPTAMINE DERIVATIVES OF GIVEN STRUCTURE | THE ROCKEFELLER UNIVERSITY (US) | 1999-11-23 | — | — | US | disclosed |
| WO-1999051591-A2 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |
| WO-1999051575-A1 | N-ARYLOXYETHYL-INDOLY-ALKYLAMINES FOR THE TREATMENT OF DEPRESSION (5-HT1A RECEPTOR ACTIVE AGENTS) | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190119278-A1 | Purine Inhibitors of Human Phosphatidylinositol 3-Kinase Delta | PIK3CD, PIK3CA, PI4KA | LOXL2 3752/4885HRH3 1158/4885MTNR1A 2110/4885 |
| US-10544147-B2 | Purine inhibitors of human phosphatidylinositol 3-kinase delta | PIK3CD, PIK3CA, PI4KA | LOXL2 3752/4885HRH3 1158/4885MTNR1A 2110/4885 |
| US-20070135647-A1 | Methods for synthesis of 3-amino-1-arylpropyl indoles | TPH1, TPH2, HTR1A | LOXL2 4456/4885HRH3 23/4885MTNR1A 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.