Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | SLC40A1 | Q9NP59 | 7/20 | 0.48 |
| ▸ | NFKBIA | P25963 | 2/20 | 0.48 |
| ▸ | RELA | Q04206 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | SGK1 | O00141 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SGK3 | Q96BR1 | 1/20 | 0.39 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1385573 | 0.83 | LMNA (0.66) | PKMSLC40A1NFKBIARELATDP1 | |
| Chlorsulfaquinoxaline SCHEMBL29557567 | 0.81 | LMNA (0.68) | TDP1MEN1KMT2ALMNACYP2C9 | |
| Chlorsulfaquinoxaline SCHEMBL6375915 | 0.81 | LMNA (0.68) | TDP1MEN1KMT2ALMNACYP2C9 | |
| SCHEMBL9231574 | 0.78 | PDPK1 (0.53) | PKMSLC40A1TDP1MEN1KMT2A | |
| SCHEMBL5323047 | 0.77 | LMNA (0.61) | PKMSLC40A1NFKBIARELATDP1 | |
| SCHEMBL23773188 | 0.77 | LMNA (0.51) | PKMMEN1KMT2ALMNACYP2C9 | |
| SCHEMBL10761503 | 0.74 | HSD11B1 (0.41) | PKMSLC40A1NFKBIARELATDP1 | |
| SCHEMBL3163793 | 0.72 | POLB (0.64) | PKMMEN1KMT2ALMNAPOLB | |
| SCHEMBL9230544 | 0.71 | HTR2C (0.45) | PKMMEN1KMT2ALMNACYP2C9 | |
| SCHEMBL9075934 | 0.71 | PIK3CD (0.45) | MEN1KMT2ALMNACYP2C9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101163468-A | Novel combination of sulfonamide compounds | EISAI R&D MAN CO LTD (JP) | 2008-04-16 | — | — | CN | claimed |
| EP-0215200-B1 | USE OF SULFANILAMIDO QUINOXALINES IN THE TREATMENT OF NEOPLASTIC DISEASES | MERCK & CO. INC. (US) | 1992-09-09 | — | — | EP | claimed |
| US-4931433-A | Method for treating certain neoplastic diseases | MERCK & CO., INC. (US) | 1990-06-05 | — | — | US | claimed |
| EP-0215200-A2 | Use of sulfanilamido quinoxalines in the treatment of neoplastic diseases | MERCK & CO. INC. (US) | 1987-03-25 | — | — | EP | claimed |
| CN-101163468-A | Novel combination of sulfonamide compounds | EISAI R&D MAN CO LTD (JP) | 2008-04-16 | — | — | CN | disclosed |
| EP-0215200-B1 | USE OF SULFANILAMIDO QUINOXALINES IN THE TREATMENT OF NEOPLASTIC DISEASES | MERCK & CO. INC. (US) | 1992-09-09 | — | — | EP | disclosed |
| US-4931433-A | Method for treating certain neoplastic diseases | MERCK & CO., INC. (US) | 1990-06-05 | — | — | US | disclosed |
| EP-0215200-A2 | Use of sulfanilamido quinoxalines in the treatment of neoplastic diseases | MERCK & CO. INC. (US) | 1987-03-25 | — | — | EP | disclosed |