SCHEMBL9703835

SCHEMBL9703835

c1ccc2c(c1)ccn2N1CCOCC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 3/20 0.39
MAPT P10636 2/20 0.39
LMNA P02545 2/20 0.39
MAPK1 P28482 2/20 0.39
USP2 O75604 1/20 0.39
ALDH1A1 P00352 1/20 0.39
RAD51 Q06609 1/20 0.38
CDK4 P11802 3/20 0.38
CCND1 P24385 3/20 0.38
MKNK1 Q9BUB5 1/20 0.38
PIK3CA P42336 2/20 0.37
KDM4E B2RXH2 1/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
MAP4K4 O95819 1/20 0.37
TSHR P16473 2/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
RAB9A P51151 1/20 0.36
PIK3CB P42338 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8087820 0.82 CDK4 (0.42) LMNAALDH1A1CDK4CCND1MEN1
SCHEMBL3717533 0.81 CDK4 (0.41) LMNAALDH1A1CDK4CCND1KDM4E
Hydrochloric Acid SCHEMBL3714611 0.79 CDK4 (0.39) LMNAALDH1A1CDK4CCND1KDM4E
SCHEMBL28745657 0.78 HTR2A (0.44) CDK4CCND1HTR2C
SCHEMBL1136602 0.78 HTR2C (0.44) LMNAMAPK1USP2ALDH1A1CDK4
SCHEMBL31195323 0.78 HTR2C (0.44) LMNAMAPK1USP2ALDH1A1CDK4
SCHEMBL21047721 0.76 TSHR (0.39) LMNAALDH1A1CDK4CCND1MEN1
SCHEMBL14911731 0.76 PRKDC (0.46) ALDH1A1PIK3CAKDM4ETSHRRAB9A
SCHEMBL15254431 0.76 PRKDC (0.40) POLBMAPTALDH1A1KDM4EMEN1
SCHEMBL18379331 0.75 CDK4 (0.54) LMNAALDH1A1CDK4CCND1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0230179-B1 4-MORPHOLINYL 1H-INDOLE DERIVATIVES, THEIR SALTS, PROCESS AND INTERMEDIATES OF PREPARATION, USE AS THERAPEUTIC AGENTS, COMPOSITIONS CONTAINING THEM ROUSSEL-UCLAF (FR) 1992-09-30 EP claimed
US-4699907-A ANTIISCHEMIC, HYPOTENSIVE AGENTS ROUSSEL UCLAF (FR) 1987-10-13 US claimed
US-4736042-A CHEMICAL INTERMEDIATES ROUSSEL UCLAF (FR) 1988-04-05 US disclosed
US-4736042-A CHEMICAL INTERMEDIATES ROUSSEL UCLAF (FR) 1988-04-05 US disclosed
US-4699907-A ANTIISCHEMIC, HYPOTENSIVE AGENTS ROUSSEL UCLAF (FR) 1987-10-13 US disclosed
US-4699907-A ANTIISCHEMIC, HYPOTENSIVE AGENTS ROUSSEL UCLAF (FR) 1987-10-13 US disclosed
US-4699907-A ANTIISCHEMIC, HYPOTENSIVE AGENTS ROUSSEL UCLAF (FR) 1987-10-13 US disclosed