SCHEMBL18379331

SCHEMBL18379331

c1ccc2c(c1)ccn2-n1ccc2ccccc21

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 4/20 0.54
CCND1 P24385 4/20 0.54
TSHR P16473 2/20 0.48
RAB9A P51151 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
NOTUM Q6P988 1/20 0.46
BIRC5 O15392 1/20 0.45
KMT2A Q03164 2/20 0.43
HTR6 P50406 2/20 0.43
PRKD3 O94806 1/20 0.43
PRKCG P05129 1/20 0.43
PRKCB P05771 1/20 0.43
PRKCA P17252 1/20 0.43
PRKACA P17612 1/20 0.43
PRKACG P22612 1/20 0.43
PRKACB P22694 1/20 0.43
PRKCH P24723 1/20 0.43
PRKCI P41743 1/20 0.43
PRKCE Q02156 1/20 0.43
PRKCQ Q04759 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29001215 0.85 CDK4 (0.46) CDK4CCND1TSHRRAB9AL3MBTL1
SCHEMBL7841838 0.79 AGER (0.48) CDK4CCND1TSHRRAB9AL3MBTL1
SCHEMBL31188174 0.79 CYP1A2 (0.47) CDK4CCND1TSHRRAB9AL3MBTL1
SCHEMBL8087820 0.79 CDK4 (0.42) CDK4CCND1TSHRRAB9AL3MBTL1
SCHEMBL3717533 0.78 CDK4 (0.41) CDK4CCND1TSHRRAB9AL3MBTL1
Hydrochloric Acid SCHEMBL3714611 0.76 CDK4 (0.39) CDK4CCND1TSHRRAB9AL3MBTL1
SCHEMBL19924469 0.76 CA12 (0.50) CDK4CCND1TSHRRAB9AL3MBTL1
SCHEMBL28618108 0.76 RECQL (0.41) CDK4CCND1TSHRRAB9AL3MBTL1
SCHEMBL1136602 0.75 HTR2C (0.44) CDK4CCND1TSHRRAB9AL3MBTL1
SCHEMBL9466193 0.75 SLC6A2 (0.41) CDK4CCND1TSHRRAB9AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210338637-A1 INDOLE DERIVATIVES FOR BIOFILM DISRUPTION AND INHIBITION Life Matters Ltd. (IL) 2021-11-04 US claimed
US-20180193310-A1 QUORUM SENSING INHIBITORS FOR BIOFILM INHIBITION Life Matters Ltd. (IL) 2018-07-12 US claimed
CN-107835685-A Quorum sensing inhibitors for inhibiting biofilms 生命物质有限公司 2018-03-23 CN claimed
WO-2025185754-A1 ORGANIC MIXTURE, ORGANIC COMPOUND, AND USE THEREOF IN ORGANIC ELECTRONIC DEVICE 浙江光昊光电科技有限公司 2025-09-12 WO disclosed
CN-119930684-A C (C)2Symmetrical N-axis chiral bisindole diphosphine ligand and preparation method and application thereof 青岛大学 2025-05-06 CN disclosed
CN-119431212-A Synthesis method of 7-bromo-5, 6-bis (benzyloxy) benzopyrrole and derivative dimer thereof 中国科学院生物物理研究所 2025-02-14 CN disclosed
US-12171909-B2 Implants having a drug load of an oxysterol and methods of use WARSAW ORTHOPEDIC, INC. (US) 2024-12-24 US disclosed
US-12171665-B2 Compression resistant implants including an oxysterol and methods of use WARSAW ORTHOPEDIC, INC. (US) 2024-12-24 US disclosed
US-20230255989-A1 GLYCAN COMPOSITIONS AND USES THEREOF DSM NUTRITIONAL PRODUCTS LLC (US) 2023-08-17 US disclosed
US-11464888-B2 Moldable formulations containing an oxysterol in an acellular tissue matrix WARSAW ORTHOPEDIC, INC. (US) 2022-10-11 US disclosed
EP-3617217-B1 PROCESS FOR THE PRODUCTION OF OXYSTEROLS WARSAW ORTHOPEDIC INC (US) 2022-09-07 EP disclosed
US-20210338637-A1 INDOLE DERIVATIVES FOR BIOFILM DISRUPTION AND INHIBITION Life Matters Ltd. (IL) 2021-11-04 US disclosed
US-20180193310-A1 QUORUM SENSING INHIBITORS FOR BIOFILM INHIBITION Life Matters Ltd. (IL) 2018-07-12 US disclosed
US-20180193310-A1 QUORUM SENSING INHIBITORS FOR BIOFILM INHIBITION Life Matters Ltd. (IL) 2018-07-12 US disclosed
US-20180193310-A1 QUORUM SENSING INHIBITORS FOR BIOFILM INHIBITION Life Matters Ltd. (IL) 2018-07-12 US disclosed
US-20180193310-A1 QUORUM SENSING INHIBITORS FOR BIOFILM INHIBITION Life Matters Ltd. (IL) 2018-07-12 US disclosed
EP-3319600-A1 QUORUM SENSING INHIBITORS FOR BIOFILM INHIBITION Life Matters Ltd. (IL) 2018-05-16 EP disclosed
CN-107835685-A Quorum sensing inhibitors for inhibiting biofilms 生命物质有限公司 2018-03-23 CN disclosed
WO-2017006331-A1 QUORUM SENSING INHIBITORS FOR BIOFILM INHIBITION KUSHMARO ARIEL (IL) 2017-01-12 WO disclosed
WO-2017006331-A1 QUORUM SENSING INHIBITORS FOR BIOFILM INHIBITION KUSHMARO ARIEL (IL) 2017-01-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12171909-B2 Implants having a drug load of an oxysterol and methods of use SOST, CYP17A1, HSD17B7 CDK4 3209/4885CCND1 1949/4885TSHR 3881/4885
US-20210338637-A1 INDOLE DERIVATIVES FOR BIOFILM DISRUPTION AND INHIBITION IDO1, IDO2, BLVRB CDK4 3080/4885CCND1 2169/4885TSHR 1999/4885
US-20180193310-A1 QUORUM SENSING INHIBITORS FOR BIOFILM INHIBITION DBI, TFPI, BLVRB CDK4 2641/4885CCND1 2291/4885TSHR 1578/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.