Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.51 |
| ▸ | RELA | Q04206 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | STAT1 | P42224 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9382103 | 0.85 | PDE4A (0.74) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10700489 | 0.82 | NPC1 (0.49) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL13341247 | 0.76 | NPC1 (0.50) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9704446 | 0.76 | CDK4 (0.42) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9703428 | 0.76 | PDE3B (0.41) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9143986 | 0.75 | NPC1 (0.56) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9143976 | 0.75 | PDE4A (0.54) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10695270 | 0.74 | NPC1 (0.50) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9379025 | 0.74 | NPC1 (0.50) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10534328 | 0.74 | PGR (0.51) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116843-A | Anticoagulants, hypotensive agents and cardiovascular disorder | BOEHRINGER MANNHEIM GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| EP-0275888-A2 | Tricyclic benzimidazoles, process for their preparation and use as medicaments | Roche Diagnostics GmbH (DE) | 1988-07-27 | — | — | EP | disclosed |