Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.49 |
| ▸ | RELA | Q04206 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | STAT1 | P42224 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.49 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.49 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9385702 | 0.86 | PDE4A (0.59) | NPC1RAB9AMAPTGAAALDH1A1 | |
| SCHEMBL10698021 | 0.84 | NPBWR1 (0.47) | NPBWR1PDE3BPDE3ACHEK2PDE4A | |
| SCHEMBL9704428 | 0.82 | PDE3B (0.54) | NPC1SMN1; SMN2RAB9AMEN1LMNA | |
| SCHEMBL9705366 | 0.80 | TP53 (0.42) | MAPTNPBWR1TP53POLBPDE3B | |
| SCHEMBL9704386 | 0.80 | PDE2A (0.39) | MEN1LMNAKMT2AMAPTALDH1A1 | |
| SCHEMBL10697321 | 0.79 | AMY1A (0.45) | NPC1RAB9AMAPTNPBWR1TP53 | |
| SCHEMBL9703298 | 0.78 | PDE5A (0.38) | NPC1RAB9AMEN1LMNAKMT2A | |
| SCHEMBL9383861 | 0.77 | CDK4 (0.41) | NPBWR1PDE3BPDE3A | |
| SCHEMBL9703362 | 0.77 | PDE5A (0.37) | MEN1LMNAKMT2AMAPTALDH1A1 | |
| SCHEMBL9379025 | 0.77 | NPC1 (0.50) | NPC1SMN1; SMN2RAB9AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275888-A2 | Tricyclic benzimidazoles, process for their preparation and use as medicaments | Roche Diagnostics GmbH (DE) | 1988-07-27 | — | — | EP | disclosed |