Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lisdexamfetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.43 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lisdexamfetamine SCHEMBL29124173 | 1.00 | MMP2 (0.59) | MMP2THRBNPC1RAB9ALTA4H | |
| Lisdexamfetamine SCHEMBL678421 | 1.00 | MMP2 (0.59) | MMP2THRBNPC1RAB9ALTA4H | |
| Lisdexamfetamine SCHEMBL158949 | 0.95 | MMP2 (0.64) | MMP2THRBNPC1RAB9ALTA4H | |
| Lisdexamfetamine SCHEMBL31439237 | 0.95 | MMP2 (0.64) | MMP2THRBNPC1RAB9ALTA4H | |
| Lisdexamfetamine SCHEMBL25674417 | 0.95 | MMP2 (0.64) | MMP2THRBNPC1RAB9ALTA4H | |
| Lisdexamfetamine SCHEMBL12947679 | 0.95 | MMP2 (0.64) | MMP2THRBNPC1RAB9ALTA4H | |
| Lisdexamfetamine SCHEMBL579061 | 0.95 | MMP2 (0.64) | MMP2THRBNPC1RAB9ALTA4H | |
| Lisdexamfetamine SCHEMBL7919487 | 0.95 | MMP2 (0.64) | MMP2THRBNPC1RAB9ALTA4H | |
| Lisdexamfetamine SCHEMBL31173641 | 0.95 | MMP2 (0.64) | MMP2THRBNPC1RAB9ALTA4H | |
| SCHEMBL972499 | 0.94 | MMP2 (0.60) | MMP2THRBNPC1RAB9ALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009669-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | SHIRE LLC (US) | 2011-01-13 | — | — | US | disclosed |
| US-7659253-B2 | Abuse-resistant amphetamine prodrugs | SHIRE LLC (US) | 2010-02-09 | — | — | US | disclosed |
| US-20090234002-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | SHIRE LLC (US) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090234002-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | COMT, CYP3A5, CYP2D6 | MMP2 2424/4885THRB 2724/4885NPC1 119/4885 |
| US-20110009669-A1 | ABUSE-RESISTANT AMPHETAMINE PRODRUGS | COMT, CYP3A5, CYP2D6 | MMP2 2424/4885THRB 2724/4885NPC1 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.