Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 2/20 | 0.44 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CCKBR | P32239 | 1/20 | 0.38 |
| ▸ | RAMP1 | O60894 | 3/20 | 0.38 |
| ▸ | CALCRL | Q16602 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9705443 | 1.00 | PLA2G10 (0.44) | PLA2G10PLA2G5SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9705835 | 1.00 | PLA2G10 (0.44) | PLA2G10PLA2G5SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL10684567 | 0.89 | PLA2G10 (0.37) | PLA2G10PLA2G5SMN1; SMN2ALDH1A1 | |
| SCHEMBL10684573 | 0.89 | PLA2G10 (0.37) | PLA2G10PLA2G5SMN1; SMN2ALDH1A1 | |
| SCHEMBL10635209 | 0.80 | PLA2G10 (0.43) | PLA2G10PLA2G5ALDH1A1CCKBR | |
| SCHEMBL9526436 | 0.80 | PLA2G10 (0.43) | PLA2G10PLA2G5ALDH1A1CCKBR | |
| SCHEMBL13929747 | 0.77 | RAMP1 (0.50) | PLA2G10PLA2G5ALDH1A1RAMP1CALCRL | |
| SCHEMBL8921216 | 0.77 | RAMP1 (0.50) | PLA2G10PLA2G5ALDH1A1RAMP1CALCRL | |
| SCHEMBL12873936 | 0.76 | CALCRL (0.41) | PLA2G10PLA2G5LMNARAMP1CALCRL | |
| SCHEMBL12873934 | 0.76 | DRD2 (0.41) | PLA2G10PLA2G5SMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220865-B1 | LACTAM DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HYPOTENSIVE AGENTS | SANKYO COMPANY LIMITED (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-4734410-A | Lactam derivatives and their use as hypotensive agents | SANKYO COMPANY LIMITED (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0220865-A2 | Lactam derivatives, their preparation and their use as hypotensive agents | SANKYO COMPANY LIMITED (JP) | 1987-05-06 | — | — | EP | disclosed |