Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL19210846 | 0.92 | CYP3A4 (0.45) | CYP3A4CYP2D6CYP2C19CYP4F2CYP4A11 | |
| SCHEMBL19233349 | 0.92 | CYP3A4 (0.45) | CYP3A4CYP2D6CYP2C19CYP4F2CYP4A11 | |
| SCHEMBL5425808 | 0.84 | L3MBTL1 (0.46) | CYP3A4CYP2D6CYP2C19ALDH1A1TDP1 | |
| SCHEMBL988882 | 0.82 | TSHR (0.48) | CYP3A4CYP2D6CYP2C19ALDH1A1SMN1; SMN2 | |
| SCHEMBL27466587 | 0.81 | CYP3A4 (0.54) | CYP3A4CYP2D6CYP2C19CYP4F2CYP4A11 | |
| SCHEMBL6544458 | 0.81 | SLC6A3 (0.41) | CYP3A4CYP2D6CYP2C19CYP4F2CYP4A11 | |
| SCHEMBL7835269 | 0.80 | HDAC1 (0.46) | CYP2D6CYP4F2CYP4A11ALDH1A1GAA | |
| SCHEMBL11263337 | 0.80 | SMN1; SMN2 (0.45) | CYP3A4ALDH1A1SMN1; SMN2TDP1POLB | |
| SCHEMBL7708867 | 0.80 | CYP3A4 (0.53) | CYP3A4CYP2D6CYP2C19CYP4F2CYP4A11 | |
| SCHEMBL29756083 | 0.78 | CYP3A4 (0.52) | CYP3A4CYP2D6CYP2C19CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220865-B1 | LACTAM DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HYPOTENSIVE AGENTS | SANKYO COMPANY LIMITED (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-4734410-A | Lactam derivatives and their use as hypotensive agents | SANKYO COMPANY LIMITED (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0220865-A2 | Lactam derivatives, their preparation and their use as hypotensive agents | SANKYO COMPANY LIMITED (JP) | 1987-05-06 | — | — | EP | disclosed |