Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10878726 | 0.89 | KDM4E (0.46) | HTTKMT2AMAOAKDM4EGPBAR1 | |
| SCHEMBL338581 | 0.87 | HTT (0.39) | HTTKMT2AMAOAKDM4EGPBAR1 | |
| SCHEMBL10373323 | 0.85 | HTT (0.44) | HTTKMT2AMAOAKDM4EGPBAR1 | |
| SCHEMBL7372957 | 0.85 | ALDH1A1 (0.47) | GPBAR1ALDH1A1NPSR1 | |
| SCHEMBL7373632 | 0.83 | GPBAR1 (0.46) | HTTMAOAGPBAR1POLBEGFR | |
| SCHEMBL7376325 | 0.82 | HTT (0.41) | HTTKMT2AMAOAKDM4EMAPT | |
| SCHEMBL10373882 | 0.81 | SIRT2 (0.43) | HTTKMT2AMAOAKDM4EGAA | |
| SCHEMBL7409011 | 0.81 | KMT2A (0.45) | HTTKMT2AMAOAKDM4EGPBAR1 | |
| SCHEMBL7366943 | 0.80 | GPBAR1 (0.44) | GPBAR1NR1H3 | |
| SCHEMBL7373570 | 0.80 | HDAC6 (0.43) | HTTKMT2AMAOAKDM4EGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0194529-B1 | USE OF 2-(AMINOPHENYL)-BENZIMIDAZOLE DERIVATIVES IN THE PREPARATION OF MEDICAMENTS FOR COMBATING MALIGN AND NON-MALIGN PROLIFERATIVE AS WELL AS AUTO-IMMUNE DISEASES AND IN IMMUNOSUPPRESSION IN TRANSPLANTATIONS | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1992-09-02 | — | — | EP | disclosed |
| US-4933368-A | FOR ADMINISTERING TO REAT REFRACTORY TUMORS IN MAMMALS | GODECKE AKTIENGESELLSCHAFT (DE) | 1990-06-12 | — | — | US | disclosed |
| US-4857662-A | N-phenylbenzamide derivatives | GODECKE AKTIENGESELLSCHAFT (DE) | 1989-08-15 | — | — | US | disclosed |
| US-4816485-A | AUTOIMMUNE DISEASES, ANTIBODY INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1989-03-28 | — | — | US | disclosed |
| EP-0194529-A2 | Use of 2-(aminophenyl)-benzimidazole derivatives in the preparation of medicaments for combating malign and non-malign proliferative as well as auto-immune diseases and in immunosuppression in transplantations | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1986-09-17 | — | — | EP | disclosed |
| EP-0116967-B1 | N-PHENYL-BENZAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1986-01-29 | — | — | EP | disclosed |
| EP-0116967-A1 | N-phenyl-benzamide derivatives, process for their preparation and medicines containing them | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1984-08-29 | — | — | EP | disclosed |