Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 12/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | POLQ | O75417 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5669153 | 0.81 | NR1H3 (0.45) | GPBAR1NR1H3HDAC6NR1H2POLQ | |
| SCHEMBL7375164 | 0.81 | CRHBP (0.47) | GPBAR1 | |
| SCHEMBL9705584 | 0.80 | HTT (0.41) | GPBAR1NR1H3 | |
| SCHEMBL7372957 | 0.78 | ALDH1A1 (0.47) | GPBAR1 | |
| SCHEMBL5476758 | 0.78 | POLQ (0.45) | GPBAR1HDAC6POLQ | |
| SCHEMBL7373632 | 0.77 | GPBAR1 (0.46) | GPBAR1 | |
| SCHEMBL25076165 | 0.76 | TSPO (0.47) | GPBAR1HDAC6POLQ | |
| SCHEMBL2088431 | 0.76 | POLQ (0.46) | GPBAR1HDAC6POLQ | |
| SCHEMBL2088432 | 0.76 | POLQ (0.50) | GPBAR1HDAC6POLQ | |
| SCHEMBL7376325 | 0.76 | HTT (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211242-B1 | CARDIOVASCULAR DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0757670-B1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-01-13 | — | — | EP | disclosed |
| EP-0757670-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029152-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-02 | — | — | WO | disclosed |