Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 1/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.56 |
| ▸ | MARK3 | P27448 | 1/20 | 0.56 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.56 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL401117 | 0.79 | PDPK1 (0.59) | CDK2PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL6747380 | 0.79 | CHEK1 (0.56) | CDK2PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL4523841 | 0.78 | CDK2 (0.51) | CDK2PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL11212991 | 0.76 | PDPK1 (0.41) | CDK2PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL2526552 | 0.75 | PDPK1 (0.44) | CDK2PDPK1LRRK2MAP3K5GDA | |
| Dimethyladenine SCHEMBL152594 | 0.72 | LRRK2 (1.00) | CDK2PDPK1CHEK1AURKACHEK2 | |
| Dimethyladenine SCHEMBL29349831 | 0.72 | LRRK2 (1.00) | CDK2PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL8851 | 0.72 | PDPK1 (0.66) | CDK2PDPK1LRRK2MAP3K5GDA | |
| SCHEMBL356178 | 0.72 | DPP4 (0.61) | CDK2PDPK1GDATNNI3KADORA3 | |
| SCHEMBL29375265 | 0.72 | PDPK1 (0.66) | CDK2PDPK1LRRK2MAP3K5GDA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992011276-A1 | NOVEL SYNTHESIS OF 2'-'UP' FLUORINATED 2''-DEOXY-ARABINOFURANOSYLPURINES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-07-09 | — | — | WO | disclosed |